| formyl | <chemistry> A univalent radical, H.C:O, regarded as the essential residue of formic acid and aldehyde. Formerly, the radical methyl, CH3. Origin: Formic + -yl. Source: Websters Dictionary (01 Mar 1998) |
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| formyl peptide | <biochemistry> Informal term for small peptides with a formylated N terminal methionine and usually a hydrophobic amino acid at the carboxy terminal end (fMetLeuPhe is the most commonly used). These peptides stimulate the motor and secretory activities of leucocytes, particularly neutrophils and monocytes, that have a specific receptor (about 60 kD) of high affinity (Kd approximately 10exp 8M). Leucocytes show chemotaxis towards formyl peptides but the term chemotactic peptides understates the range of activities the molecules will trigger. Thought to be synthetic analogues of bacterial signal sequences though this is unproven. The leucocytes of many animals (e.g. Pig, cow, chicken) do not respond. (18 Nov 1997) |
| formyl sterol oxidase | <enzyme> Converts sterol 4-aldehyde to a carboxylic acid in presence of NADH or NADPH Registry number: EC 1.2.1.- (26 Jun 1999) |
| formyl-coenzyme A transferase | <enzyme> From oxalbacter formigenes; has been sequenced; genbank u82167 Registry number: EC 2.8.3.- Synonym: formyl-CoA transferase, frc gene product (26 Jun 1999) |
| formyl-methenyl-methylenetetrahydrofolate synthetase | <chemical> Trifunctional enzyme which contains EC 6.3.4.3, formyltetrahydrofolate synthetase, plus EC 3.5.4.9, methenyltetrahydrofolate cyclohydrolase, and EC 1.5.1.5, methylenetetrahydrofolate dehydrogenase as a complex in sheep liver Chemical name: synthetase, formyl-methenyl-methylenetetrahydrofolate Synonym: c1-thf synthase, c1-tetrahydrofolate synthase, formyl-methenyl-methylenetetrahydrofolate synthetase (combined), c-1-tetrahydrofolate synthetase, nadp-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase (26 Jun 1999) |
| formylase | <enzyme> Isolated from methylophilus methylotrophus; genbank x99632 Registry number: EC 3.5.1.49 Synonym: fmda gene product (26 Jun 1999) |
| formylglutamate amidohydrolase | <enzyme> From pseudomonas putida; degrades formylglutamate to glutamate and formate Registry number: EC 3.5.1.- Synonym: n-formyl-l-glutamate amidohydrolase (26 Jun 1999) |
| formylmethanofuran dehydrogenase | <enzyme> Catalyses the oxidation of formylmethanofuran to co2 and methanofuran with methyl viologen as artificial electron acceptor; from methanogenic bacteria Registry number: EC 1.2.99.5 Synonym: fmf dehydrogenase, fmdabc gene product (26 Jun 1999) |
| formylmethanofuran-tetrahydromethanopterin formyltransferase | <enzyme> From methanobacterium thermoautotrophicum; role in methanogenesis from co2 Registry number: EC 2.1.2.- Synonym: fmf-tmp formyltransferase (26 Jun 1999) |
| formylmethionine | Methionine acylated on the NH2 group by a formyl (-CHO) group. This is the starting amino acid residue for virtually all bacterial polypeptides. See: initiating codon. Synonym: N-formylmethionine. (05 Mar 2000) |
| formylmethionyl-tRNA | Initiation tRNA in certain organisms. (05 Mar 2000) |
| formyltetrahydrofolate deformylase | <enzyme> From rat or pig liver homogenates; catalyses the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and formate; amino acid sequence has been determined Registry number: EC 3.5.1.10 Synonym: formyltetrahydrofolate hydrolase, 10-formyltetrahydrofolate amidohydrolase, fthf hydrolase, puru protein, puru gene product (26 Jun 1999) |
| formyltetrahydrofolates | Tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-formyltetrahydrofolate is leukovorin (citrovorum factor) while n(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions. (12 Dec 1998) |
| active formyl | The formyl group taking part in transformylation reactions with a folic acid derivative in the role of carrier. (05 Mar 2000) |
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| hydroxymethyl and formyl transferases | <enzyme> Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. Registry number: EC 2.1.2 (12 Dec 1998) |
| 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic acid dehydrogenase | <enzyme> Nad+ dependent; from pseudomonas ma-1 grown on pyridoxine; involved in vitamin b6 degradation Registry number: EC 1.1.1.- Synonym: fhmpc dehydrogenase (26 Jun 1999) |