| folic acid conjugate | A folate with three molecules of glutamic acid (pteropterin) instead of one, or with seven (pteroylheptaglutamic acid or vitamin Bc conjugate). (05 Mar 2000) |
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| folic acid | <biochemistry> Pteridine derivative that is abundant in liver and green plants and is a growth factor for some bacteria. The biochemically active form is tetrahydrofolate (see folate). (12 Nov 1997) |
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| folic acid antagonist | <pharmacology> A chemical which inhibits a cells capacity to use folic acid and so prevent cell division, for example methotrexate. See: chemotherapy. (12 Nov 1997) |
| folic acid antagonists | Inhibitors of the enzyme, dihydrofolate reductase (tetrahydrofolate dehydrogenase), which converts dihydrofolate (fh2) to tetrahydrofolate (fh4). They are frequently used in cancer chemotherapy. (12 Dec 1998) |
| folic acid deaminase | <enzyme> Chemotaxis regulating enzyme; splits folic acid into 6-hydroxymethylpterin and p-aminobenzoylglutamic acid Registry number: EC 3.5.4.- Synonym: folic acid inactivating enzyme, folic acid c9-n10 cleaving enzyme (26 Jun 1999) |
| folic acid deficiency | A nutritional condition produced by a deficiency of folic acid in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anaemia, macrocytic anaemia, and megaloblastic anaemia. It is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed) (12 Dec 1998) |
| folic acid deficiency anaemia | Anaemia due to deficiency of folic acid, characterised by large-sized red blood cells (macrocytosis) and presence of large nuclei in erythroid precursor cells (megaloblasts) in the bone marrow. (05 Mar 2000) |
| folic acid oxidase | <enzyme> Enzyme from human red blood cell membranes; catalyses oxidation of folic acid to pterin-6-aldehyde plus p-aminobenzoylglutamic acid in presence of h2o2; singlet oxygen is involved Registry number: EC 1.11.- (26 Jun 1999) |
| conjugate acid | The protonated compound of two compounds that differ in structure only by the presence of the labile proton. (05 Mar 2000) |
| conjugate acid-base pair | In prototonic solvents (e.g., H2O, NH3, acetic acid), two molecular species differing only in the presence or absence of a hydrogen ion (e.g., carbonic acid/bicarbonate ion or ammonium ion/ammonia); the basis of buffer action. (05 Mar 2000) |
| vaccines, conjugate | Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognised by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection. (12 Dec 1998) |
| wheat germ agglutinin-horseradish peroxidase conjugate | <chemical> The lectin wheatgerm agglutinin conjugated to the enzyme horseradish peroxidase. It is widely used for tracing neural pathways. Pharmacological action: molecular probes. (12 Dec 1998) |
| conjugate | Paired together. In chemistry, this refers to an acid and a base which can convert to each other by the gain or loss of a proton (a hydrogen nucleus), which together are called a conjugate acid-base pair. It can also refer to two liquids in equilibrium with each other. In mycology (the study of fungi), this refers to a dikaryon with two haploid nuclei in it. (09 Oct 1997) |
| conjugate axis | Distance from the promontory of the sacrum to the upper posterior edge of the pubic symphysis. Synonym: anteroposterior diameter of the pelvic inlet, conjugata vera, conjugate axis, conjugate diameter of pelvic inlet, diameter mediana, internal conjugate, true conjugate. (05 Mar 2000) |
| conjugate deviation of the eyes | Rotation of the eyes equally and simultaneously in the same direction, as occurs normally, a condition in which both eyes are turned to the same side as a result of either paralysis or muscular spasm. (05 Mar 2000) |
| conjugate diameter of pelvic inlet | Distance from the promontory of the sacrum to the upper posterior edge of the pubic symphysis. Synonym: anteroposterior diameter of the pelvic inlet, conjugata vera, conjugate axis, conjugate diameter of pelvic inlet, diameter mediana, internal conjugate, true conjugate. (05 Mar 2000) |