| focal sclerosis with hyalinosis | <nephrology> A kidney disorder that results in fibrosis and scarring in the kidney glomerulus. The cause is unknown but some cases can result from reflux nephropathy. The clinical manifestation of this kidney disorder is nephrotic syndrome. Symptoms include weight gain, swelling, hypertension and foamy urine. High blood cholesterol and triglyceride levels are also seen with this disorder. Treatment has included the use of corticosteroids and immunosuppressives. Antihypertensive agents and diuretics may also be necessary. Over one-half will develop chronic renal failure within 10 years of diagnosis. (27 Sep 1997) |
|---|
| focal and segmental hyalinosis | <nephrology> A kidney disorder that results in fibrosis and scarring in the kidney glomerulus. The cause is unknown but some cases can result from reflux nephropathy. The clinical manifestation of this kidney disorder is nephrotic syndrome. Symptoms include weight gain, swelling, hypertension and foamy urine. High blood cholesterol and triglyceride levels are also seen with this disorder. Treatment has included the use of corticosteroids and immunosuppressives. Antihypertensive agents and diuretics may also be necessary. Over one-half will develop chronic renal failure within 10 years of diagnosis. (27 Sep 1997) |
|---|---|
| focal sclerosis | <neurology> Neurodegenerative disease characterised by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in 3rd or 4th decade with intermittent progression over an extended period. Cause still uncertain. (18 Nov 1997) |
| hyalinosis | Hyaline degeneration, especially that of relatively extensive degree. (05 Mar 2000) |
| systemic hyalinosis | A rare recessively inherited deforming disorder of head, neck, and generalised cutaneous nodules or tumours in children with normal mentality; the lesions consist of fibroblasts separated by an eosinophilic hyalin stroma composed mostly of glycosaminoglycans. Synonym: systemic hyalinosis. (05 Mar 2000) |
| Alzheimer's sclerosis | Hyaline degeneration of the medium and smaller blood vessels of the brain. (05 Mar 2000) |
| amyotrophic lateral sclerosis | A serious neurologic disease that results from the progressive degeneration of the motor neurons. (27 Sep 1997) |
| amyotropic lateral sclerosis | A chronic progressive disease of motor neurons (the nerves that come from the spinal cord to supply electrical energy to the muscles). (12 Dec 1998) |
| arterial sclerosis | <cardiology, disease> Imprecise term for various disorders of arteries, particularly hardening due to fibrosis or calcium deposition, often used as a synonym for atherosclerosis. (17 Oct 1997) |
| arteriocapillary sclerosis | Arteriosclerosis, especially of the finer vessels. (05 Mar 2000) |
| arteriolar sclerosis | <cardiology, disease> Sclerosis and thickening of the walls of the smaller arteries (arterioles). Hyaline arteriolosclerosis, in which there is homogeneous pink hyaline thickening of the arteriolar walls, is associated with benign nephrosclerosis. Hyperplastic arteriolosclerosis, in which there is a concentric thickening with progressive narrowing of the lumina may be associated with malignant hypertension, nephrosclerosis and scleroderma. (17 Oct 1997) |
| bone sclerosis | <medicine> A condition of bone cartilage occurring in certain diseases of these tissues, in which they acquire an unnatural density, and come to resemble ivory. Origin: L. Eburnus of ivory, fr. Ebur ivory: cf. F. Eburnation. See Ivory. Source: Websters Dictionary (01 Mar 1998) |
| Canavan's sclerosis | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
| valvular sclerosis | Fibrosis, often with calcification of valves, considered to be an aging change and not due to primary valvular disease. (05 Mar 2000) |
| vascular sclerosis | <cardiology, disease> Imprecise term for various disorders of arteries, particularly hardening due to fibrosis or calcium deposition, often used as a synonym for atherosclerosis. (17 Oct 1997) |
| mantle sclerosis | A common cerebral lesion in the palsied states of early life characterised by nodular cortical atrophy. (05 Mar 2000) |