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¿µ¹® serum enzyme ÇÑ±Û Ç÷ûȿ¼Ò
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¿µ¹® enzyme ÇÑ±Û È¿¼Ò
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  »ý¹°Ã¼ ¼¼Æ÷¼Ó¿¡¼­ ÇÕ¼ºµÇ°í, ÁַΠ¼¼Æ÷³»¿¡¼­ ÁøÇàµÇ´Â È­ÇйÝÀÀÀ» Ã˸ÅÇϴ ´Ü¹éÁú·Î ½ÃÇè°ü³»¿¡¼­µµ °°Àº Ã˸ÅÀÛ¿ëÀ» ÇÑ´Ù. ÀÌ È¿¼Ò´Â ÀΰøÀûÀ¸·Î ¸¸µç ¾î¶² Ã˸ÅÁ¦º¸´Ù ±× Æ¯À̼º°ú Ã˸ÅÀÛ¿ëÀ̠Ź¿ùÇѠƯº°ÇÑ »ýüºÐÀÚÀÌ´Ù. ½ÅÁø´ë»ç, Áï ¼¼Æ÷³»¿¡¼­ ÀϾ´Â ¹°ÁúÀÇ È­ÇÐÀû º¯È¯Àº È¿¼ÒÀÇ ÀÛ¿ë¿¡ ÀÇÇØ ¸Å¿ì ºü¸£°í ¿øÇÒÇϰԠÀÌ·ç¾îÁø´Ù. À̰ÍÀº È¿¼ÒÀÇ Ã˸ŠȿÀ²ÀÌ ³ôÀº Á¡°ú È¿¼ÒÀÇ ±âÁú Æ¯À̼º ¶§¹®ÀÌ´Ù. È¿¼Ò¹ÝÀÀÀº »ó¿Â, »ó¾Ð, ÃÖÀû pH µî ÀûÀýÇÑ Á¶°Ç ¾Æ·¡¿¡¼­ ÁøÇàµÈ´Ù. ¶Ç È¿¼ÒÀÇ ÁÖü°¡ ´Ü¹éÁúÀ̱⠶§¹®¿¡ ´Ü¹éÁúÀ» º¯¼º½Ã۴ ¿­, °­»ê, °­¾ËÄ®¸®, À¯±â¿ë¸Å µî¿¡ ÀÇÇØ ±× ÀÛ¿ëÀ» ÀҴ´Ù. È¿¼Ò´Â »ýü¿¡ ³Î¸® ºÐÆ÷Çϸç, º¹ÀâÇÏ°í ´Ù¾çÇÑ ´ë»ç¹ÝÀÀÀ» Ã˸ÅÇϱ⠶§¹®¿¡ Á¾·ùµµ ¸¹´Ù. ¾Õ¼­ ¸»ÇÑ ¹Ù¿Í °°ÀÌ ´ëºÎºÐÀÇ È¿¼Ò´Â ¼¼Æ÷³»¿¡ Á¸ÀçÇÏÁö¸¸, Ç÷¾×°ú ±×¿ÜÀÇ °£Áú¾×¿¡ µé¾î Àֱ⵵ ÇÏ°í ¼ÒÈ­È¿¼Ò·ù󷳠ü¿Ü·Î ºÐºñµÇ´Â °Íµµ ÀÖ´Ù.
¿µ¹® enzyme-linked immunoabsorbent assay ÇÑ±Û È¿¼Ò¸é¿ªÃøÁ¤¹ý
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  È¿¼Ò°áÇո鿪ÈíÂøÁ¦ °ËÁ¤¹ýÀ¸·Î ¹ø¿ªµÇ°í ÀÖ´Ù. ÀÌ ¹ýÀº Ç׿ø(¶Ç´Â Ç×ü)¿¡ ¾ËÄ®¸® Æ÷½ºÆÄŸ¾ÆÁ¦ ¶Ç´Â Æä¸£¿Á½Ãµð¾ÆÁ¦ µîÀÇ »ê¼Ò¸¦ °áÇÕ½ÃÄÑ µÎ°í ±× »ê¼ÒȰ¼ºÀ» ÁöÇ¥·Î »ï¾Æ Ç׿øÇ×ü¹ÝÀÀÀÇ Á¤µµ¸¦ ¾È ´ÙÀ½ ¿©±â¿¡¼­ Ç׿ø(¶Ç´Â Ç×ü)ÀÇ ¾çÀ» ±¸Çϴ °ÍÀÌ´Ù. ÀÌ ¹ýÀÇ ÀÌÁ¡À¸·Î¼­ °í°¨µµ, Á¶ÀÛÀÇ °£´ÜÇÔ ¹× ¹æ»ç¼±¸é¿ªÃøÁ¤¹ýó·³ ¹æ»ç¼º¹°ÁúÀ» »ç¿ëÇÏÁö ¾Ê¾Æµµ µÈ´Ù´Â Á¡À» µé ¼ö ÀÖ´Ù. È£¸£¸óÀ̳ª ¸é¿ª±Û·ÎºÒ¸°ÀÇ Á¤·®¹ýÀ¸·Î¼­ ÀÀ¿ë µÇ°í ÀÖÀ¸¸ç ÃøÁ¤¿ë Å°Æ®µµ ½ÃÆÇµÇ°í ÀÌÀÖ´Ù.
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  • ¿µ¹®
    ÇѱÛ
  • chemical kinetics
    È­ÇйÝÀÀ¼Óµµ·Ð
  • kinetics
    1. ¿ªµ¿ÇÐ 2. -µ¿ÇÐ
  • angiotensin converting enzyme
    ¾ØÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò
  • angiotensin converting enzyme inhibitor
    ¾ØÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò¾ïÁ¦Á¦
  • antibody capture enzyme-linked immunosorbent assay
    Ç×üÆ÷ȹȿ¼Ò¸é¿ªÃøÁ¤(¹ý)
  • autolytic enzyme
    ÀÚ°¡¿ëÇØÈ¿¼Ò
  • adaptive enzyme
    ÀûÀÀÈ¿¼Ò
  • allosteric enzyme
    ¾Ë·Î½ºÅ׸®È¿¼Ò
  • blood enzyme level
    Ç÷ÁßÈ¿¼Ò³óµµ
  • brancher enzyme
    °¡ÁöÄ¡±âÈ¿¼Ò, ºÐÁöÈ¿¼Ò
  • branching enzyme
    °¡ÁöÄ¡±âÈ¿¼Ò, ºÐÁöÈ¿¼Ò
  • constitutive enzyme
    ±âº»±¸¼ºÈ¿¼Ò
  • converting enzyme inhibitor
    Àüȯȿ¼Ò¾ïÁ¦Á¦
  • cytosolic enzyme
    ¼¼Æ÷¾×È¿¼Ò
  • debrancher enzyme
    °¡ÁöÁ¦°ÅÈ¿¼Ò, Å»ºÐÁöÈ¿¼Ò
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  • ¿µ¹®
    ÇѱÛ
  • kinetics
    µ¿·ÂÇÐ, ¿îµ¿ÇÐ
  • enzyme-linked immunosorbent assay
    È¿¼Ò¸é¿ªÃøÁ¤¹ý
  • enzyme
    È¿¼Ò
  • angiotensin converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò
  • inhibitory enzyme
    ¾ïÁ¦È¿¼Ò
  • oxidative enzyme
    »êÈ­È¿¼Ò
  • proteolytic enzyme
    ´Ü¹éÁúºÐÇØÈ¿¼Ò
  • rate limiting enzyme
    ¼ÓµµÁ¶ÀýÈ¿¼Ò
  • redox enzyme
    »êȭȯ¿øÈ¿¼Ò
  • regulatory enzyme
    Á¶ÀýÈ¿¼Ò
  • respiratory enzyme
    È£ÈíÈ¿¼Ò
  • restriction enzyme
    Á¦ÇÑÈ¿¼Ò
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  • ¿µ¹®
    ÇѱÛ
  • chemical kinetics
    È­ÇйÝÀÀ¼Óµµ·Ð
  • kinetics
    µ¿¿ªÇÐ, ¿îµ¿ÇÐ
  • adaptive enzyme
    ÀûÀÀÈ¿¼Ò
  • allosteric enzyme
    ¾Ë·Î½ºÅ׸®È¿¼Ò
  • angiotensin converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò
  • antibody capture enzyme-linked immunosorbent assay
    Ç×üÆ÷ȹȿ¼Ò¸é¿ªÃøÁ¤¹ý
  • autolytic enzyme
    ÀÚ°¡¿ëÇØÈ¿¼Ò
  • double-sandwich enzyme-linked immunosorbent assay
    °ãÈ¿¼Ò¸é¿ªÃøÁ¤¹ý
  • enzyme activity
    È¿¼ÒȰ¼º, È¿¼ÒȰ¼ºµµ
  • enzyme assay
    È¿¼ÒÃøÁ¤
  • enzyme labeled antibody
    È¿¼ÒÇ¥ÁöÇ×ü
  • enzyme-linked immunosorbent assay
    È¿¼Ò¸é¿ªÃøÁ¤¹ý
  • blood enzyme level
    Ç÷ÁßÈ¿¼Ò³óµµ
  • branching enzyme
    °¡ÁöÄ¡±âÈ¿¼Ò, ºÐÁöÈ¿¼Ò
  • enzyme-linked immunoelectrotransfer blot
    È¿¼Ò¸é¿ªÀÌÀû¹ý, È¿¼Ò¿¬°ü¸é¿ªÀü±âÀü´ÞÁ¡
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  • ¿µ¹®
    ÇѱÛ
  • reaction kinetics
    ¹ÝÀÀ¼Óµµ·Ð(ÚãëëáÜöôÖå).
  • ACE : angiotensin converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò.
  • ACE=> angiotensin converting enzyme
    ¾ÈÁö¿ÀÅٽŠÀüȯȿ¼Ò(ï®üµý£áÈ)
  • ACEI : angiotensin converting enzyme inhibitor
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò¾ïÁ¦Á¦(ï®ü½ý£áÈåäð¤ð¥).
  • Converting enzyme
    Àüȯȿ¼Ò(ï®üµý£áÈ)
  • ELISA => enzyme-linked immunosorbent assay
    ¿¤¶óÀÌÀÚ
  • EMMIA => enzyme modulator mediated immunoassay
    È¿¼ÒÁ¶Àý¸Å°³¸é¿ªÃøÁ¤
  • adaptive enzyme
    ÀûÀÀÈ¿¼Ò(îêëëý£áÈ).
  • allosteric enzyme
    ¾Ë·Î½ºÅ׸®È¿¼Ò(¡­ý£áÈ).
  • angiotensin converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò.
  • angiotensin converting enzyme inbibitor
    ¾ÈÁö¿ÀÅٽŠÀüȯȿ¼Ò ¾ïÁ¦¹°Áú<¾à>.
  • angiotensin converting enzyme inhibitor
    ¾ÈÁö¿ÀÅٽŠÀüȯȿ¼Ò ¾ïÁ¦¹°Áú<¾à>.
  • angiotensin-converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò
  • antibody, enzyme-labelled
    È¿¼ÒÇ¥ÁöÇ×ü
  • glycolytic enzyme
    ÇØ´çÈ¿¼Ò.
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  • ¿µ¹®
    ÇѱÛ
  • chemical kinetics
    È­ÇÐÀû¹ÝÀÀ¼Óµµ·Ð.
  • kinetics
    ¿ªÇÐ
  • kinetics
    ¼Óµµ·Ð(áÜÓøÖå), µ¿ÅÂ(ÔÑ÷¾), ¿îµ¿ÇÐ(ê¡ÔÑùÊ).
  • neutrophil kinetics
    È£Áß¼º Ű³×ƽ½º, È£Áß¼º µ¿ÅÂ(~ËÄ̬).
  • reaction kinetics
    ¹ÝÀÀ¼Óµµ·Ð(ÚãëëáÜöôÖå).
  • tumor growth,kinetics of
    ¡­ÀÇ ¼Óµµ·Ð(¿ªµ¿, µ¿ÅÂ)
  • adaptive enzyme
    ÀûÀÀÈ¿¼Ò(îêëëý£áÈ).
  • allosteric enzyme
    ¾Ë·Î½ºÅ׸®È¿¼Ò(¡­ý£áÈ).
  • angiotensin converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò.
  • angiotensin converting enzyme inbibitor
    ¾ÈÁö¿ÀÅٽŠÀüȯȿ¼Ò ¾ïÁ¦¹°Áú<¾à>.
  • angiotensin converting enzyme inhibitor
    ¾ÈÁö¿ÀÅٽŠÀüȯȿ¼Ò ¾ïÁ¦¹°Áú<¾à>.
  • angiotensin-converting enzyme
    ¾ÈÁö¿ÀÅÙ½ÅÀüȯȿ¼Ò
  • antibody, enzyme-labelled
    È¿¼ÒÇ¥ÁöÇ×ü
  • ase =enzyme
    È¿¼Ò.
  • assay, enzyme-linked immuno(ad)sorbent (ELISA)
    È¿¼Ò¸é¿ªÃøÁ¤¹ý
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  • ¿µ¹®
    ÇѱÛ
  • enzyme-linked immunoelectrotransfer blot (EITB)
    È¿¼Ò¸é¿ªÀÌÀû¹ý
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  • ¿µ¹®
    ÇѱÛ
  • enzyme kinetics
    È¿¼Ò¿ªµ¿ÇÐ(ý£áÈæ³ÔÑùÊ)
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  • ¿µ¹®
    ÇѱÛ
  • chemical kinetics
    È­ÇÐÀû ¹ÝÀÀ¼Óµµ·Ð(ûùùÊîÜ ÚãëëáÜÓøÖå)
  • cooperative kinetics
    Çùµ¿ ¿ªµ¿ÇÐ(úðÔÒÕôÔÑùÊ)
  • first-order kinetics
    ÀÏÂ÷ ¿ªµ¿ÇÐ (ìéó­ æ³ÔÑùÊ)
  • hyperbolic kinetics
    ½Ö°î¼± ¿ªÇÐ(äªÍØàÊÕôùÊ)
  • kinetics
    "1. ¹ÝÀÀ¼Óµµ·Ð(ÚãëëáÜÓøÖå), 2. ¹ÝÀÀ°úÁ¤(ÚãëëΦïï), 3. ¿ªÇÐ(ÕôùÊ), 4. ¿îµ¿ÇÐ(ê¡ÔÑùÊ)"
  • Michaelis-Menten kinetics
    ¹ÌŰ¿¤¸®½º-¸àÅÙ ¿ªµ¿ÇÐ(æ³ÔÑùÊ)
  • pre-steady-state kinetics
    ÀüÁ¤À¯»óÅÂ(îñïÒë§ßÒ÷¾) ¿ªÇÐ(ÕôùÊ)
  • pseudo-first-order kinetics
    À§ÀÏÂ÷¿ªÇÐ(êÊìéó­ÕôùÊ)
  • rapid flow kinetics
    ±Þ·ù¿ªµ¿ÇÐ(Ðá×µæ³ÔÑùÊ)
  • reaction kinetics
    ¹ÝÀÀ ¼Óµµ·Ð(ÚãëëáÜÓøÖå)
  • reassociation kinetics
    ÀçȸÇÕ ¿ªµ¿ÇÐ(î¢üåùêæ³ÔÑùÊ)
  • relaxation kinetics
    ÀÌ¿Ï ¿ªµ¿ÇÐ(ì¬èÐæ³ÔÑùÊ)
  • saturation kinetics
    Æ÷È­ ¿ªÇÐ(øéûùÕôùÊ)
  • sigmoid kinetics
    SÀÚÇü(í®úþ) ¿ªµ¿ÇÐ(æ³ÔÑùÊ)
  • steady-state kinetics
    Á¤·ù»óÅ ¿ªÇÐ (ïÒ׺ßÒ÷¾ÕôùÊ)
KI ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 4 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • ELISA [=enzyme-linked immunosorbent assay]
    ELIZA, ¿¤¸®ÀÚ
  • enzyme
    È¿¼Ò
  • enzyme-linked immunosorbent assay [=ELISA]
    ELISA, ¿¤¸®ÀÚ
  • proteolytic enzyme
    ´Ü¹éÁúºÐÇØÈ¿¼Ò
KMLE ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
EIA electroimmunoassay; enzyme immunoassay; enzyme-linked immunosorbent assay; equine infectious anemia;...
PACE Pacing and Clinical Electrophysiology; paired basic amino acid cleaving enzyme; personalized aerobic...
ACE Angiotensin Converting Enzyme
  = Kininase II
  = Dipeptidyl Carboxypepti...
EIA   1) Exercise Induced Asthma; ¿îµ¿ À¯¹ß¼º õ½Ä
  = EIB
  2) Enzyme Immu...
ELISA Enzyme-Linked Immuno-Sorbent Assay; È¿¼Ò ¸é¿ª¹ý
KMLE ÀÚµ¿ÃßÃâ ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
ELISA Enzyme Linked Immuno Sorbant Assay
ACE ANG I converting enzyme
ACE ANGIOTENSIN CONVERTING ENZYME
ACEI Angiotensin Converting Enzyme Inhibitor
ACEi Angiotensin I converting enzyme inhibition
°æºÏ´ë Ä¡°ú´ëÇÐ ±¸°­³»°ú ±³½Ç »çÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
    ¼³¸í
  • cell kinetics
    ¼¼Æ÷ ¿ªÇÐ
  • chemical kinetics
    È­ÇÐÀû ¹ÝÀÀ ¼Óµµ·Ð
  • kinetics
    µ¿·ÂÇÐ, ¹ÝÀÀ ¼Óµµ·Ð, µ¿ÅÂ, ¿îµ¿ÇÐ
    Ư¼öÇÑ ÀÎÀÚÀÇ º¯È¯ ¶Ç´Â º¯È­ÀÇ ºñÀ²¿¡ °üÇÑ µ¿·ÂÇÐÀÇ ºÐÆÄ. º¸Åë ´ÜÀ§ ½Ã°£¸¶´ÙÀÇ ´ÜÀ§·®À¸·Î¼­ Ç¥½ÃµÈ´Ù.
  • angiotensin converting enzyme
    ¾ÈÁö¿ÀÅٽŠÀüȯ È¿¼Ò
  • angiotensin-converting enzyme
    ¾ÈÁö¿ÀÅٽŠÀüȯ È¿¼Ò
  • converting enzyme
    Àüȯ È¿¼Ò
  • digestive enzyme
    ¼ÒÈ­ È¿¼Ò
  • enzyme activator
    È¿¼Ò Ȱ¼ºÁ¦
  • enzyme disorder
    È¿¼Ò Àå¾Ö
  • enzyme immunoassay
    È¿¼Ò ¸é¿ª ÃøÁ¤¹ý
    ¼Ò·®ÀÌ¶óµµ ±× Ȱ¼ºÀ» °ËÃâÇÒ ¼ö ÀÖ´Â °í°¨µµÀÇ È¿¼Ò¸¦ Ç¥½ÃÀÚ·Î Çϰí Ç׿ø ȤÀº Ç×ü, ³ª¾Æ°¡¼­´Â ƯÀÌÀûÀ¸·Î ¹ÝÀÀÇÏ´Â ¹°Áú, lectin, C1q µîÀ» È­ÇÐÀûÀ¸·Î °áÇÕ½ÃÄÑ, Ç׿ø ȤÀº Ç×ü µûÀ§¸¦ ÃøÁ¤ÇÏ´Â ¹æ¹ýÀÌ´Ù.
  • enzyme inhibition
    È¿¼Ò ¾ïÁ¦
  • enzyme labeled antibody
    È¿¼Ò Ç¥Áö Ç×ü
  • enzyme marker study
    È¿¼Ò Ç¥Áö ¿¬±¸
  • enzyme precursor
    È¿¼Ò Àü±¸Ã¼
  • enzyme-labelled antibody
    È¿¼Ò Ç¥Áö Ç×ü
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
second-order kinetics A term describing the reaction rate of a chemical reaction in which the rate is proportional to the product of the concentrations (in moles) of two of the reactants (also called bimolecular kinetics), or to the square of the molar concentration of the reactant if there is only one. Such a reaction might have an equation like rate = k[A][B] or rate = k[A]2, where k is the reaction rate constant, [A] is the concentration of reactant A, and [B] is the concentration of reactant B.
(09 Oct 1997)
third-order kinetics <pharmacology> A term describing the reaction rate of a chemical reaction in which the rate is proportional to the product of the concentrations (in moles) of three of the reactants, the product of the molar concentration of one reactant and the square of the molar concentration of another reactant, or the cube of the molar concentration of one of the reactants.
Such a reaction might have an equation like rate = k[A][B][C] or rate = [A][B]2 or rate = [A]3, where k is the reaction rate constant, [A] is the concentration of reactant A, [B] is the concentration of reactant B, and [C] is the concentration of reactant C.
(09 Oct 1997)
kinetics <physics> See Dynamics.
Source: Websters Dictionary
(01 Mar 1998)
first-order kinetics A term describing the reaction rate of a chemical reaction in which the rate is proportional to the concentration (in moles) of only one of the reactants. Such a reaction might have an equation like rate = k[A], where k is the reaction rate constant and [A] is the concentration of a reactant A.
(09 Oct 1997)
acetyl-activating enzyme A ligase that catalyses the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate.
Synonym: acetate thiokinase, acetate-CoA ligase, acetyl-activating enzyme, acetyl-CoA synthetase.
(05 Mar 2000)
acyl-activating enzyme <enzyme> Fatty acid thiokinase (long-chain), a ligase forming acyl-CoA, AMP, and pyrophosphate from long-chain fatty acids, ATP, and coenzyme A. Activity is independent of phosphatidylcholine
Registry number: EC 6.2.1.3
Synonym: acyl-activating enzyme, dodecanoyl-CoA synthetase, fatty acid thiokinase (long chain), acid-coenzyme a ligase, fatty acid-CoA ligase, acyl-CoA synthetase, acyl-CoA ligase, coash ligase, ciprofibroyl-CoA synthetase, pristanoyl-CoA synthetase, palmityl CoA synthetase, palmitoyl CoA synthetase, palmitoyl CoA ligase, fatty acyl-CoA synthetase, very long chain fatty acid acyl-CoA synthetase, vlcfa acyl-CoA synthetase, nafenopin-CoA ligase, palmitoyl-CoA synthase, faa2 gene product, faa2p protein, vlacs enzyme
(26 Jun 1999)
adaptive enzyme Inducible enzyme, an enzyme that can be detected in a growing culture of a microorganism, after the addition of a particular substance (inducer) to the culture medium, but was not detectable prior to the addition and can act on the inducer. A prototype is the beta-galactosidase of Escherichia coli, synthesised upon the addition of various galactosides, whether or not these are good substrates.
Compare: constitutive enzyme.
Synonym: adaptive enzyme.
(05 Mar 2000)
allosteric enzyme <biochemistry, chemistry> A regulatory enzyme whose activity is modified by the noncovalent binding of a particular metabolite at a site (the allosteric site) other than the active site.
(09 Oct 1997)
amino acid activating enzyme <enzyme> Enzymes catalyzing the formation of a specific aminoacyl-tRNA from an amino acid and adenosine 5'-triphosphate with the concomitant formation of adenosine 5'-monophosphate and pyrophosphate.
Synonym: amino acid activating enzyme, aminoacyl-tRNA ligases.
(05 Mar 2000)
angiotensin-converting enzyme <enzyme> This hydrolase enzyme cleaves the decapeptide angiotensin I (biologically inactive) to form active angiotensin II by angiotensin-converting enzyme which removes a dipeptide (histidylleucine) from angiotensin I.
Angiotensin II causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands. Angiotensin is finally broken down by angiotensinases.
Elevations in angiotensin converting enzyme are seen sarcoidosis, histoplasmosis, alcoholic cirrhosis, asbestosis, berylliosis, diabetes, Hodgkin's disease, hyperthyroidism, amyloidosis, primary biliary cirrhosis, idiopathic pulmonary fibrosis, pulmonary embolism, scleroderma, silicosis, tuberculosis, Gaucher's disease and leprosy. The normal values are 18 to 67 U/ml over 20 years of age (people under 20 have higher levels).
Drugs that inhibit ACE are used to treat hypertension and congestive heart failure.
See: angiotensin-converting enzyme inhibitor
Acronym: ACE
(12 Aug 2000)
angiotensin-converting enzyme inhibitor <pharmacology> A class of drugs used in the treatment of hypertension and heart failure.
They exert their haemodynamic effect mainly by inhibiting the renin-angiotensin system and produce a reduction of peripheral arterial resistance. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
(14 Aug 2000)
angiotensin-converting enzyme secretase <enzyme> Converts ace from a membrane-bound to a soluble form; not inhibited by thiol, serine or acid enzyme inhibitor but is inhibited by edta and 1,10-phenanthroline
Registry number: EC 3.4.99.-
Synonym: ace secretase
(26 Jun 1999)
Antibody Directed Enzyme Prodrug Therapy <pharmacology> A method for targeting a drug to a specific tissue, in which the targeting agent and the drug are administered separately.
The drug is designed to be inactive (a prodrug) until it is converted by an enzyme, which is the targeting agent. The enzyme is coupled to an antibody that directs it to the tissue of interest. When the enzyme arrives at the tissue, the prodrug is activated only at that site, sparing other tissues from potentially toxic side effects.
Acronym: ADEPT
(14 Nov 1997)
antitumour enzyme <enzyme> An enzyme that stimulates the degradation of a particular metabolite that cannot be synthesised by tumour cells, inhibits the synthesis of a metabolite needed by tumour cells, or inhibits tumour-specific DNA utilization; e.g., asparaginase.
(05 Mar 2000)
autolytic enzyme <enzyme> An enzyme capable of causing lysis of the cell forming it.
(05 Mar 2000)
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