| end | 1. The extreme or last point or part of any material thing considered lengthwise (the extremity of breadth being side); hence, extremity, in general; the concluding part; termination; close; limit; as, the end of a field, line, pole, road; the end of a year, of a discourse; put an end to pain; opposed to beginning, when used of anything having a first part. "Better is the end of a thing than the beginning thereof." (Eccl. Vii. 8) 2. Point beyond which no procession can be made; conclusion; issue; result, whether successful or otherwise; conclusive event; consequence. "My guilt be on my head, and there an end." (Shak) "O that a man might know The end of this day's business ere it come!" (Shak) 3. Termination of being; death; destruction; extermination; also, cause of death or destruction. "Unblamed through life, lamented in thy end." (Pope) "Confound your hidden falsehood, and award either of you to be the other's end." (Shak) "I shall see an end of him." (Shak) 4. The object aimed at in any effort considered as the close and effect of exertion; ppurpose; intention; aim; as, to labour for private or public ends. "Losing her, the end of living lose." (Dryden) "When every man is his own end, all things will come to a bad end." (Coleridge) 5. That which is left; a remnant; a fragment; a scrap; as, odds and ends. "I clothe my naked villainy With old odd ends stolen out of holy writ, And seem a saint, when most I play the devil." (Shak) 6. One of the yarns of the worsted warp in a Brussels carpet. An end. On end; upright; erect; endways. To the end; continuously. <anatomy> End bulb, one of the two plates of a jewel in a timepiece; the part that limits the pivot's end play. Ends of the earth, the remotest regions of the earth. In the end, finally. On end, upright; erect. To the end, in order. To make both ends meet, to live within one's income. To put an end to, to destroy. Origin: OE. & AS. Ende; akin to OS. Endi, D. Einde, eind, OHG. Enti, G. Ende, Icel. Endir, endi, Sw. Ande, Dan. Ende, Goth. Andeis, Skr. Anta. Cf. Ante-, Anti-, Answer. Source: Websters Dictionary (01 Mar 1998) |
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| end artery | <anatomy, artery> An artery with insufficient anastomoses to maintain viability of the tissue supplied if occlusion of the artery occurs. Synonym: terminal artery. (05 Mar 2000) |
| end bud | The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. Synonym: end bud. (05 Mar 2000) |
| end bulb | One of the oval or rounded bodies in which the sensory nerve fibres terminate in mucous membrane. (05 Mar 2000) |
| end cell | A fully differentiated cell, the mature cell of a lineage. (05 Mar 2000) |
| end organ | The special structure containing the terminal of a nerve fibre in peripheral tissue such as muscle, tissue, skin, mucous membrane, or glands. See: ending. (05 Mar 2000) |
| end oxidation | <biochemistry> The last oxidation step in a catabolic pathway. Synonym: terminal oxidation. (05 Mar 2000) |
| end plate | <anatomy, physiology> The area of sarcolemma immediately below the synaptic region of the motor neuron in a neuromuscular junction. most often refers to the end of a nerve fibre against a skeletal muscle fibre, to which it transmits nerve signals. (18 Nov 1997) |
| end plate potential | <physiology> Depolarisation of the sarcolemma as a result of acetylcholine release from the motoneuron causing an influx of sodium ions. The endplate potential is the sum of quantal miniature endplate potentials. Development of the end plate potential is blocked by curare. (18 Nov 1997) |
| end point | <chemistry> It is the completion point during a titration reaction where there are equal amounts of titrant and whatever is being titrated. It is usually evident by the first perceptible alteration of the colour of an added indicator. <immunology> It is the most dilute an antibody or antiserum solution can be while still detectably reacting with the antigen. <statistics> A category of data used to compare the outcome in different arms of a clinical trial. Common endpoints are severe toxicity, disease progression or fall in such surrogate markers as CD4 count, but sometimes death is used as an endpoint. (08 Mar 2000) |
| end product | <biochemistry> The final product of after a series of reactions with enzymes in a biochemical metabolic pathway has taken place. (09 Oct 1997) |
| end product inhibition | <biochemistry, physiology> The process of the end product of a particular metabolic reaction inhibiting an allosteric enzyme involved in that reaction as the reaction starts again, thus breaking the reaction cycle. (09 Oct 1997) |
| end product repression | Catabolite repression in which the catabolite is an end product of a particular pathway. (05 Mar 2000) |
| end stage | The late, fully developed phase of a disease; e.g., in end-stage renal disease, a shrunken and scarred kidney that may result from a variety of chronic diseases that have become indistinguishable in their effect on the kidney. (05 Mar 2000) |
| end-brush | An anomalous term that refers to the terminal arborization of an axon. Synonym: end-brush. Origin: G. Telos, end, + dendron, tree (05 Mar 2000) |
| acromial end of clavicle | The flattened lateral end of the clavicle that articulates with the acromion and is anchored to the coracoid process by the conoid and trapezoid ligaments. Synonym: extremitas acromialis claviculae, acromial end of clavicle. (05 Mar 2000) |
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| blunt-end | Refers to double-stranded DNA in which there are no unpaired bases at the end. (05 Mar 2000) |
| blunt-end DNA | <molecular biology> A fragment of a DNA molecule in which the ends of both strands are even with each other rather than one strand being longer than the other. (09 Oct 1997) |
| blunt-end ligation | A lab technique to join together two pieces of blunt-end DNA, such as an insert into a cloning vector, which requires the enzyme ligase because there are no single-stranded overhanging ends for the attachment to form more spontaneously, by itself. (09 Oct 1997) |
| by-end | Private end or interest; secret purpose; selfish advantage. Alternative forms: bye-end. (20 Mar 1998) |
| capped 5'-end | A methylated (has a -CH3 attached) guanosine nucleotide attached to the 5'-end (the beginning) of an eukaryotic mRNA, thought to give the mRNA stability. (09 Oct 1997) |
| glycosylation end products, advanced | Products derived from the nonenzymatic reaction of glucose and proteins in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of diabetes mellitus. (12 Dec 1998) |
| root end cyst | An inflammatory odontogenic cyst derived histogenetically from Malassez' epithelial rests surrounding the root apex of a nonvital tooth. Synonym: periapical cyst, radicular cyst, root end cyst. (05 Mar 2000) |
| root end granuloma | Chronic nonsuppurative inflammation of periapical tissue resulting from irritation following pulp disease or endodontic treatment. (12 Dec 1998) |
| miniature end plate potential | <physiology> Small fluctuations (typically 0.5 mV) in the resting potential of postsynaptic cells. They are the same shape as, but much smaller than, the end plate potentials caused by stimulation of the presynaptic cell. Miniature end plate potentials are considered as evidence for the quantal release of neurotransmitters at chemical synapses, a single miniature end plate potential resulting from the release of the contents of a single synaptic vesicle. (12 Jan 1998) |
| positive end-expiratory pressure | A technique used in respiratory therapy in which airway pressure greater than atmospheric pressure is achieved at the end of exhalation by introduction of a mechanical impedance to exhalation. (05 Mar 2000) |
| skin test end-point titration | A quantitative form of intradermal testing for the relative allergenicity of a substance. It is used to determine the amount of an allergen that will be tolerated in immunotherapy. (12 Dec 1998) |
| negative end-expiratory pressure | A subatmospheric pressure at the airway at the end of expiration. (05 Mar 2000) |
| sternal end of clavicle | The enlarged medial end of the clavicle that articulates with the manubrium sterni. Synonym: extremitas sternalis claviculae, sternal end of clavicle. (05 Mar 2000) |
| dead-end host | A host from which infectious agents are not transmitted to other susceptible host's. (05 Mar 2000) |