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eif-2 Eukaryotic initiation factor of protein synthesis. The factor consists of three subunits, alpha, beta, and gamma. As initiation proceeds, eif-2 forms a ternary complex with met-trnai and GTP.
(12 Dec 1998)
eif-2 kinase <enzyme> A dsrna-activated camp-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsrna and ATP, eif-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyses the phosphorylation of the alpha subunit of eif-2, leading to the inhibition of protein synthesis.
Registry number: EC 2.7.10.-
(12 Dec 1998)
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