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"eIF-2 stimulating protein"¿¡ ´ëÇÑ °Ë»ö °á°úÀÔ´Ï´Ù. °Ë»ö °á°ú º¸´Â µµÁß¿¡ Tab ۸¦ ´©¸£½Ã¸é °Ë»ö âÀÌ ¼±Åõ˴ϴÙ.
¾Ë±â½¬¿î ÀÇÇпë¾îÇ®ÀÌÁý, ¼­¿ïÀÇ´ë ±³¼ö ÁöÁ¦±Ù, °í·ÁÀÇÇÐ ÃâÆÇ À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
¿µ¹® protein ÇÑ±Û ´Ü¹éÁú
¼³¸í   
  Åº¼Ò, ¼ö¼Ò, »ê¼Ò, Áú¼Ò, È²À» ÇÔÀ¯Çϰí Àִ À¯±âÈ­ÇÕ¹°·Î, ¸ðµç ¼¼Æ÷ÀÇ ¿øÇüÁúÀ» ÀÌ·ç°í Àִ ±âº» ±¸¼º¹°ÁúÀÌ´Ù. ´Ü¹éÁúÀº ±× ´ÜÀ§ÀΠ¾Æ¹Ì³ë»êµéÀÌ ÆéƼµå°áÇÕ¿¡ ÀÇÇØ °áÇյǾî ÀÖÀ¸¸ç, º¸Åë 20°³ÀÇ ¾Æ¹Ì³ë»êµéÀÌ ´Ù¸¥ ¼ø¼­¿Í Á¶¼ºÀ» °¡Áö°í ¹è¿­µÇ¾î, µ¶Æ¯ÇÑ ÇϳªÀÇ ´Ü¹éÁúÀ» Çü¼ºÇϰԠµÈ´Ù.
´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • colony-stimulating factor
    Áý¶ôÀÚ±ØÀÎÀÚ
  • follicle stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó
  • granulocyte colony-stimulating factor
    °ú¸³±¸Áý¶ôÀÚ±ØÀÎÀÚ
  • granulocyte-macrophage colony-stimulating factor
    °ú¸³±¸Å«Æ÷½Ä¼¼Æ÷Áý¶ôÀÚ±ØÀÎÀÚ, °ú¸³±¸´ë½Ä±¸Áý¶ôÀÚ±ØÀÎÀÚ
  • interstitial cell-stimulating hormone
    »çÀÌÁú¼¼Æ÷ÀÚ±ØÈ£¸£¸ó, °£Áú¼¼Æ÷ÀÚ±ØÈ£¸£¸ó
  • lymphocytosis stimulating factor
    ¸²ÇÁ±¸Áõ°¡ÀÚ±ØÀÎÀÚ
  • macrophage colony-stimulating factor
    Å«Æ÷½Ä¼¼Æ÷Áý¶ôÀÚ±ØÀÎÀÚ, ´ë½Ä¼¼Æ÷Áý¶ôÀÚ±ØÀÎÀÚ
  • melanocyte-stimulating hormone
    ¸á¶ó´Ñ¼¼Æ÷ÀÚ±ØÈ£¸£¸ó
  • antifreeze protein
    Ç×µ¿°á´Ü¹éÁú
  • antiviral protein
    Ç×¹ÙÀÌ·¯½º´Ü¹éÁú
  • adherence protein
    ºÎÂø´Ü¹éÁú
  • androgen binding protein
    ¾Èµå·Î°Õ°áÇմܹéÁú
  • Bence Jones protein
    º¥½º-Á¸½º´Ü¹éÁú
  • coat protein
    ¿ÜÇǴܹéÁú
  • competitive protein binding radioassay
    °æÇմܹéÁú°áÇÕ¹æ»çÃøÁ¤(¹ý)
´ëÇÑÀÇÇù Çʼö ÀÇÇпë¾îÁý »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 11 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • follicle stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó
  • melanocyte-stimulating hormone
    ¸á¶ó´Ñ¼¼Æ÷ÀÚ±ØÈ£¸£¸ó
  • purified follicle stimulating hormone
    ¼ø¼ö³­Æ÷ÀÚ±ØÈ£¸£¸ó
  • thyroid stimulating hormone
    °©»ó»ùÀÚ±ØÈ£¸£¸ó
  • protein binding
    ´Ü¹é°áÇÕ
  • protein-losing enteropathy
    ´Ü¹é¼Ò½ÇâÀÚº´Áõ
  • protein
    ´Ü¹é, ´Ü¹éÁú
  • adherence protein
    ºÎÂø´Ü¹é
  • reserve protein
    ÀúÀå´Ü¹é
  • split-timed urine protein
    ½Ã°£´ëº°¿ä´Ü¹éÁ¤·®
  • structural protein
    ±¸Á¶´Ü¹é, ±¸Á¶´Ü¹éÁú
¿¾ ´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • colony-stimulating factor
    Áý¶ôÀÚ±ØÀÎÀÚ
  • follicle-stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó
  • granulocyte colony-stimulating factor
    °ú¸³±¸Áý¶ôÀÚ±ØÀÎÀÚ
  • granulocyte-macrophage colony-stimulating factor
    °ú¸³±¸Å«Æ÷½Ä¼¼Æ÷Áý¶ôÀÚ±ØÀÎÀÚ
  • lymphocytosis stimulating factor
    ¸²ÇÁ±¸Áõ°¡ÀÚ±ØÀÎÀÚ
  • macrophage colony-stimulating factor
    Å«Æ÷½Ä¼¼Æ÷Áý¶ôÀÚ±ØÀÎÀÚ
  • interstitial cell-stimulating hormone
    »çÀÌÁú¼¼Æ÷ÀÚ±ØÈ£¸£¸ó
  • melanocyte-stimulating hormone
    ¸á¶ó´Ñ¼¼Æ÷ÀÚ±ØÈ£¸£¸ó
  • thyroid-stimulating hormone
    (¢¡thyrotropin) ¹æÆÐ»ùÀÚ±ØÈ£¸£¸ó, °©»ó»ùÀÚ±ØÈ£¸£¸ó
  • minimal stimulating test
    ¹Ì¾àÁÖÀÔÀڱؽÃÇè
  • adherence protein
    ºÎÂø´Ü¹é
  • antifreeze protein
    Ç×µ¿°á´Ü¹éÁú
  • protein binding
    ´Ü¹é°áÇÕ
  • carrier protein
    ¿î¹Ý´Ü¹é, ¿î¹Ý´Ü¹éÁú
  • catabolite activating protein
    ÀÌÈ­»ê¹°È°¼ºÈ­´Ü¹é
¿¾ ´ëÇÑÀÇÇù 2 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • B cell stimulating factor (BSF)
    B¼¼Æ÷ ÀÚ±ØÀÎÀÚ
  • FSH= follicle stimulating hormone
    ³­Æ÷ÀÚ±Ø(Õ°øàí©Ð½)È£¸£¸ó.
  • FSH= follicle stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó.
  • Fetal thyroid-stimulating hormone
    žư©»ó¼±ÀÚ±Ø(÷Ãä®Ë£ßÒàÍí©Ð½)È£¸£¸ó
  • G-CSF (Granulocyte colony-stimulating factor)
    °ú¸³¼¼Æ÷±ºÃËÁøÀÎÀÚ(Î¨Ø£á¬øàÏØõµòäì×í­)
  • ICSH = interstitial cell stimulating hormone
    °£Áú¼¼Æ÷ÀÚ±Ø(Êàòõá¬øàí©Ð½)È£¸£¸ó.
  • ICSH=£¾interstitial cell stimulating hormone
    °£Áú¼¼Æ÷ÀÚ±ØÈ£¸£¸ó.
  • Macrophage colony-stimulating factor
    ´ë½Ä¼¼Æ÷Áý¶ôÇü¼ºÃËÁøÀÎÀÚ(ÓÞãÝá¬øàó¢Õªû¡à÷õµòäì×í­)à÷õµòäì×?
  • TSH=£¾thyroid stimulating hormone
    °©»ó¼±ÀÚ±ØÈ£¸£¸ó
  • TSH=£¾thyroid stimulating hormone
    °©»ó¼±ÀÚ±ØÈ£¸£¸ó.
  • adrenergic stimulating drug
    ¾Æµå·¹³¯¸°ÈïºÐ¾à, ¾Æµå·¹³¯¸°ÀÚ±ØÁ¦.
  • appetite stimulating agent
    ½Ä¿åÃËÁø¾à(¡­õµòäå·).
  • appetite stimulating agent
    ½Ä¿åÀÚ±ØÁ¦
  • ganglionic stimulant =g. stimulating agent
    ½Å°æÀýÈïºÐ¾à(¡­ýéÝÇå·).
  • granulocyte colony-stimulating factor
    °ú¸³±¸Áý¶ôÀÚ±ØÀÎÀÚ
¿¾ ´ëÇÑÀÇÇù 3 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • adrenergic drug =a. stimulating agent
    ¾Æµå·¹³¯¸°¾à.
  • adrenergic drug =a. stimulating agent
    ¾Æµå·¹³¯¸°¼º¾à¹°
  • adrenergic drug =a. stimulating agent
    ¾Æµå·¹³¯¸°(¼º)¾à.
  • adrenergic stimulating drug
    ¾Æµå·¹³¯¸°ÈïºÐ¾à, ¾Æµå·¹³¯¸°ÀÚ±ØÁ¦.
  • adrenergic stimulating drug
    ¾Æµå·¹³¯¸°(¼º)ÈïºÐ¾à, ¾Æµå·¹³¯¸°(¼º)ÀÚ±ØÁ¦.
  • appetite stimulating agent
    ½Ä¿åÃËÁø¾à(¡­õµòäå·).
  • appetite stimulating agent
    ½Ä¿åÀÚ±ØÁ¦
  • beta receptor stimulating agent
    º£Å¸¼ö¿ëü ÀÚ±ØÁ¦( -áôé»ô÷ í©Ð½ð¥)
  • colony stimulating factor
    Áý¶ôÀÚ±ØÀÎÀÚ(ó¢Õªí©Ð½ì×í­)
  • colony stimulating factor 1 (CSF-1)
    Áý¶ôÀÚ±ØÀÎÀÚ-1, ¼¼Æ÷±ºÀÚ±ØÀÎÀÚ-1
  • colony-stimulating factor
    Áý¶ôÀÚ±ØÀÎÀÚ
  • follicle stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó
  • follicle stimulating hormone
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó(Õ°øàí©Ð½¡­)
  • follicle stimulating hormone =FSH
    ³­Æ÷ÀÚ±ØÈ£¸£¸ó(Õ°øàô§Ð½¡­).
  • follicle stimulating principle
    ³­Æ÷ÀڱؼººÐ(Õ°øàí©Ð½à÷ÝÂ).
´ëÇÑÇØºÎÇÐȸ ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • Protein granule
    ´Ü¹éÁú°ú¸³
    [¿¾ ¿ë¾î] ´Ü¹éÁú°ú¸³
´ëÇѱâ»ýÃæÇÐȸ ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 4 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • adherence protein
    ºÎÂø´Ü¹éÁú
  • circumsporozoite protein (CSP)
    Æ÷ÀÚ¼Òü¸·´Ü¹éÁú
  • protein layer
    ´Ü¹éÁúÃþ
  • stage-specific protein
    ¹ßÀ°´Ü°èƯÀ̴ܹéÁú
´ëÇÑ»ýÈ­ÇкÐÀÚ»ý¹°ÇÐȸ ¿ë¾î »çÀü °Ë»ö ¸ÂÃã °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • eIF-2 stimulating protein
    eIF-2 ÀÚ±Ø ´Ü¹éÁú(í©Ð½Ó±ÛÜòõ)
´ëÇÑ»ýÈ­ÇкÐÀÚ»ý¹°ÇÐȸ ¿ë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • colony-stimulating factor
    ÄݷδÏÀÚ±Ø ÀÎÀÚ(í©Ð½ì×í­)
  • follicle-stimulating hormone
    ³­Æ÷ÀÚ±Ø(Õ°øàí©Ð½) È£¸£¸ó
  • follicle-stimulating hormone releasing hormone
    ³­Æ÷ÀÚ±Ø(Õ°øàí©Ð½) È£¸£¸ó ¹æÃâ(Û¯õó) È£¸£¸ó
  • insulin stimulating test
    Àν¶¸° ÀڱؽÃÇè(í©Ð½ãËúÐ)
  • interstitial cell-stimulating hormone
    °£Áú¼¼Æ÷(Êàòõá¬øà)ÀÚ±Ø(í©Ð½) È£¸£¸ó
  • melanocyte-stimulating hormone
    ¸á¶ó´Ñ¼¼Æ÷ÀÚ±Ø(á¬øàí©Ð½) È£¸£¸ó
  • melanocyte-stimulating hormone regulatory hormone
    ¸á¶ó´Ñ¼¼Æ÷ÀÚ±Ø(á¬øàí©Ð½) È£¸£¸ó Á¶Àý(ðàï½) È£¸£¸ó
  • melanocyte-stimulating hormone rease-inhibiting hormone
    ¸Þ¶ó´Ñ¼¼Æ÷ÀÚ±Ø(á¬øàí©Ð½) È£¸£¸ó À¯¸® ÀúÇØ(ë´×îîÁúª) È£¸£¸ó
  • melanocyte-stimulating hormone releasing hormone
    ¸Þ¶ó´Ñ¼¼Æ÷ÀÚ±Ø(á¬øàí©Ð½) È£¸£¸ó À¯¸®(ë´×î) È£¸£¸ó
  • thyroid-stimulating hormone
    °©»ó¼±ÀÚ±Ø (Ë£ßÒàÍí©Ð½) È£¸£¸ó
  • thyroid-stimulating hormone releasing hormone
    °©»ó¼±ÀÚ±Ø (Ë£ßÒàÍí©Ð½) È£¸£¸ó À¯¸®(ë´×î)È£¸£¸ó
  • accelerator protein
    ÃËÁø´Ü¹éÁú (õµòäÓ±ÛÜòõ)
  • acyl-carrier protein
    ¾Æ½Ç¿î¹Ý ´Ü¹éÁú (ê¡ÚæÓ±ÛÜòõ)
  • ada protein
    ada ´Ü¹éÁú
  • adhesion protein
    ºÎÂø´Ü¹éÁú(ݾó·Ó±ÛÜòõ)
KI ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 10 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • stimulating
    ÈïºÐ¼ºÀÇ
  • Bence-Jones protein
    º¥½º-Á¸½º´Ü¹é
  • C-reactive protein
    C-¹ÝÀÀ¼º´Ü¹éÁú
  • high protein diet
    °í´Ü¹é½ÄÀÌ
  • plasma protein
    Ç÷Àå´Ü¹éÁú
  • protein
    ´Ü¹é(Áú)
  • protein metabolism
    ´Ü¹é(Áú)´ë»ç
  • protein-losing enteropathy
    ´Ü¹é»ó½Ç¼ºÀ庴Áõ
  • protein-losing gastroenteropathy
    ´Ü¹é»ó½Ç¼ºÀ§ÀåÁõ
  • serum protein
    Ç÷û´Ü¹é
KMLE ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
MAP malignant atrophic papulosis; mandibular angle plane; maturation-activated protein; maximal aerobic ...
MBP major basic protein; maltose-binding protein; management by policy; mannose-binding protein; mean bl...
RP radial pulse; radiopharmaceutical; rapid processing [of film]; Raynaud phenomenon; reactive protein;...
LSH lutein-stimulating hormone; lymphocyte-stimulating hormone
MSH medical self-help; melanocyte-stimulating hormone; melanophore-stimulating hormone
KMLE ÀÚµ¿ÃßÃâ ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
GM-CSF Granulocyte colony-stimulating factor , granulocyte-macrophage colony-stimulating factor
G-CSF Granulocyte-Macrophage Colony-Stimulating Factor , Granulocyte Colony-Stimulating Factor
ASP Acylation Stimulating Protein
MSP Macrophage Stimulating Protein
MSH 1-melanocyte-stimulating hormone
°æºÏ´ë Ä¡°ú´ëÇÐ ±¸°­³»°ú ±³½Ç »çÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
    ¼³¸í
  • adrenergic stimulating drug
    ¾Æµå·¹³¯¸° ÈïºÐ ¾à, ¾Æµå·¹³¯¸°¼º ÈïºÐ¾à, ¾Æµå·¹³¯¸° ÀÚ±ØÁ¦, ¾Æµå·¹³¯¸°¼º ÀÚ±ØÁ¦
  • B cell stimulating factor 1
    B ¼¼Æ÷ ÃËÁø ÀÎÀÚ 1
    µ¿ÀǾî´Â Interleukin 4·Î ¾Ë·ÁÁø ´ç´Ü¹éÀ¸·Î¼­ T ¼¼Æ÷, ºñ¸¸¼¼Æ÷ µî¿¡¼­ »ý»êµÈ´Ù. À̰ÍÀº B ¼¼Æ÷¿¡ ´ëÇØ comitogenÀ¸·Î ÀÛ¿ëÇϴµ¥ ±× ¿µÇâÀº B ¼¼Æ÷ÀÇ ¼º¼÷µµ¿¡ µû¶ó ´Ù¸£´Ù.
  • colony stimulating factor
    ±ºÃ¼ ÀÚ±Ø ¿ä¼Ò, Áý¶ô ÀÚ±Ø ÀÎÀÚ
    ¹ß´Þ ´Ü°èÀÇ Àü±¸Àû ¼¼Æ÷°¡ Áý¶ôÀ» Çü¼ºÇÏ´Â °úÁ¤¿¡´Â À̰ÍÀÇ ÀÛ¿ëÀÌ ÇÊ¿äÇÏ´Ù´Â °ÍÀÌ ÀνĵǾú´Ù. ÀÌ ÀÎÀÚ´Â ¼¶À¯¾Æ¼¼Æ÷, ³»ÇǼ¼Æ÷, ´ë½Ä¼¼Æ÷ µî¿¡¼­ »ý»êµÇ¸ç ¼º¼÷ÇÑ ¸é¿ª°è ¼¼Æ÷ÀÇ ÀÛ¿ë¿¡µµ ¿µÇâÀ» ³¢Ä£´Ù.
  • follicle stimulating hormone releasing factor
    ³­Æ÷ ÀÚ±Ø È£¸£¸ó ¹æÃâ ÀÎÀÚ
  • human thyroid stimulating hormone
    »ç¶÷ °©»ó¼± ÀÚ±Ø È£¸£¸ó
  • melanocyte stimulating hormone
    Èæ»ö ¼¼Æ÷ ÀÚ±Ø È£¸£¸ó
  • melanocyte-stimulating hormone
    Èæ»ö ¼¼Æ÷ ÀÚ±Ø È£¸£¸ó, ¸á¶ó´Ñ ¼¼Æ÷ ÀÚ±Ø È£¸£¸ó
    ³úÇϼöü Áß¿±¿¡¼­ ºÐºñµÇ¸é¼­ ü»ö º¯È­¿¡ °ü°èÇϴ ȣ¸£¸ó. ¸á¶ó³ëÆ®·ÎÇÉ
  • abnormal protein
    ºñÁ¤»ó ´Ü¹éÁú
  • activated protein C resistance
    Ȱ¼ºÈ­ C ´Ü¹é ³»¼º
  • acute phase protein
    ±Þ¼º±â ´Ü¹éÁú
    °¨¿°À̳ª Á¶Á÷ ¼Õ»óÀÌ ÀÖÀ» ¶§ Á¤»óº¸´Ù 2-100¹è Á¤µµ Áõ°¡ÇÏ´Â Ç÷Àå ´Ü¹éÁúÀ» ÃÑĪÇÏ¿© APP¶ó°í ÇÏ¸ç ¼±Ãµ¼º ¸é¿ª¿¡ °ü¿©ÇÑ´Ù.
  • androgen binding protein
    ³²¼º È£¸£¸ó °áÇÕ ´Ü¹é
  • bacterio protein
    ¼¼±Õ ´Ü¹éÁú
  • body protein
    ü´Ü¹é, ü´Ü¹éÁú
  • C-reactive protein
    C-¹ÝÀÀ ´Ü¹é, C-¹ÝÀÀ¼º ´Ü¹éÁú
  • cellular retinoid acid-binding protein
    ¼¼Æ÷³» ·¹Æ¼³ëÀ̵å»ê °áÇÕ ´Ü¹é
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
adrenal androgen-stimulating hormone A putative pituitary hormone that may be responsible for increased secretion of adrenal androgens at the time of puberty.
(05 Mar 2000)
macrophage colony-stimulating factor <growth factor> A glycoprotein growth factor that causes the committed cell line to proliferate and mature into macrophages.
A cytokine synthesised by mesenchymal cells that stimulates pluripotent stem cells of bone marrow into differentiating towards the production of monocytes (mononuclear phagocytes).
The compound stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. It is a disulfide-bonded glycoprotein dimer with a mw of 70 kD and binds to a single class of high affinity receptor which is identical to the product of the c-fms proto-oncogene.
See: colony-stimulating factors.
Chemical name: Colony-stimulating factor 1
Acronym: M-CSF
(12 Dec 1998)
receptors, colony-stimulating factor Cell surface receptors for colony-stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of haemopoietic cells.
(12 Dec 1998)
receptors, granulocyte-colony-stimulating factor Receptors that bind and internalise granulocyte-colony-stimulating factor. Their mw is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells.
(12 Dec 1998)
receptors, granulocyte-macrophage colony-stimulating factor Receptors that bind and internalise the granulocyte-macrophage stimulating factor. Their mw is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor.
(12 Dec 1998)
receptors, macrophage colony-stimulating factor Glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response.
(12 Dec 1998)
melanocyte-stimulating hormone <endocrinology> A releasing hormone produced in the mammalian hypophysis and related structures in lower vertebrates. Made up of _ MSH (1665D), the same as amino acids 1-13 of ACTH and _ MSH (18 amino acids, 22 in humans). Causes darkening of the skin by expansion of the melanophores but its role in mammals is unclear.
Synonym: melanotropin.
Acronym: MSH
(22 Sep 2002)
granulocyte-colony-stimulating factor <growth factor, haematology, oncology> A glycoprotein of 25 kD containing internal disulfide bonds.
It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukaemic myeloid cell lines.
A protein that stimulates the growth and maturation of granulocytes. It is used to promote the recovery of the white cells following chemotherapy.
See: colony-stimulating factor.
Acronym: G-CSF
(12 Dec 1998)
granulocyte-macrophage colony-stimulating factor <growth factor, haematology, oncology> An acidic glycoprotein of mw 23 kD with internal disulfide bonds.
It is produced in response to a number of inflammatory mediators by mesenchymal cells present in the haemopoietic environment and at peripheral sites of inflammation.
It stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from foetal liver progenitor cells. It also has some functional activities in mature granulocytes and macrophages.
It is used to promote the recovery of the white blood cells following chemotherapy.
Chemical name: Colony-stimulating factor 2
See: colony-stimulating factor.
Acronym: GM-CSF
(12 Dec 1998)
colony-stimulating factor <cell biology> A glycoprotein growth factor that regulates the differentiation of particular cells.
These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically and can exert actions on several lines of progenitor cells, and influence end cell function. These lymphokines induce the maturation and proliferation of white blood cells from the primitive cell types present in bone marrow such as the leucocyte, macrophage and monocyte lines.
These substances can also be made by recombinant DNA technology for use clinically to speed bone marrow recovery typically following chemotherapy.
Acronym: CSF
(18 Jul 2002)
multi-colony-stimulating factor <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells.
A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors.
Synonym: multi-CSF
Acronym: IL-3
(12 Dec 1998)
multipotential colony-stimulating factor <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells.
A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors.
Synonym: multi-CSF
Acronym: IL-3
(12 Dec 1998)
hormone, thyroid stimulating A hormone produced by the pituitary gland (at the base of the brain) that promotes the growth of the thyroid gland (in the neck) and stimulates it to produce its thyroid hormones. Normally, the rate of thyroid hormone production is controlled by the pituitary. When there are insufficient thyroid hormones in the body for normal functioning of the cells, the pituitary releases tsh. Tsh in turn stimulates the thyroid gland to produce more thyroid hormones. In contrast, when there is excessive amount of thyroid hormones, the pituitary gland stops producing tsh. The tsh level then falls and thyroid hormone production is reduced. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood. This phenomenon is analogous to a thermostat used for temperature regulation in a room: when the temperature rises, the thermostat shuts the heater off and the room temperature falls back to normal. High levels of thyroid hormones cause the tsh level to fall, resulting in no further stimulation of the thyroid gland. In hyperthyroidism, there are continuously elevated levels of the thyroid hormones. Tsh is also known as thyrotropin.
(12 Dec 1998)
natural killer cell stimulating factor <cytokine> A 75 kD heterodimeric cytokine composed of disulfide-bonded 40 kD and 35 kD subunits that was originally identified by its ability to induce cytotoxic effector cells in synergy with less than optimal concentrations of interleukin-2.
It is released by macrophages in response to infection and promotes the activation of cell-mediated immunity. Specifically, IL-12 triggers the maturation of Thl CD4 cells, specific cytotoxic T-lymphocyte responses and an increase in the activity of NK cells and consequently, it is the initiator of cell-mediated immunity.
It enhances the lytic activity of NK cells, induces interferon production, stimulates the proliferation of activated T-cells and NK cells. Is secreted by human B lymphoblastoid cells (NC 37). May play a role in controlling immunoglobulin isotype selection as it also inhibits IgE synthesis (even in the presence of anti-IFN monoclonal antibody) and as a growth factor for activated CD4+ and CD8+ T-cells independently of interleukin-2, and for CD56+ NK cells but not resting peripheral blood mononuclear cells or resting or activated tonsillar B-cells.
It is likely that interleukin 12 has a major role in protective immunity against viruses and is under study as an immunotherapy in HIV infection.
Formerly referred to as cytotoxic lymphocyte maturation factor.
Acronym: IL-12
(12 Dec 1998)
immunoglobulins, thyroid-stimulating Autoantibodies that bind to the thyroid-stimulating hormone (tsh) receptor (receptors, thyrotropin) on thyroid epithelial cells. The autoantibodies mimic tsh causing an unregulated production of thyroid hormones characteristic of graves' disease.
(12 Dec 1998)
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