| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
|---|---|
| acid intoxication | Poisoning by acid products (beta-oxybutyric acid, diacetic acid, or acetone) formed as a result of faulty metabolism (e.g., uncontrolled diabetes mellitus) or by acids introduced from without; marked by epigastric pain, headache, loss of appetite, constipation, restlessness, and an odour of acetone in the breath, followed by air hunger, coma, and collapse. (05 Mar 2000) |
| alcoholic intoxication | A condition caused by the ingestion of alcohol in which control of one's faculties is impaired and inhibitions are broken. In its later stages one tends toward or reaches insensibility. (webster, 3d ed) (12 Dec 1998) |
| anaphylactic intoxication | Intoxication following an anaphylactic reaction. (05 Mar 2000) |
| citrate intoxication | A toxic condition that may develop during massive replacement therapy with transfused blood that contains citrate as an anticoagulant; the citrate combines with calcium ions and may result in tetany. (05 Mar 2000) |
| water intoxication | The condition induced by the undue retention of water with sodium depletion. It is marked by lethargy, nausea, vomiting, and mild mental aberrations, and in severe cases by convulsions and coma. (12 Dec 1998) |
| septic intoxication | Systemic disease associated with the presence and persistence of pathogenic microorganisms or their toxins in the blood. Synonym: blood poisoning. See: bacteraemia. Origin: Gr. Haima = blood (11 Jan 1998) |
| intestinal intoxication | A disorder resulting from absorption of the waste products of metabolism, decomposed matter from the intestine, or the products of dead and infected tissue as in gangrene. Synonym: autotoxicosis, endogenic toxicosis, enterotoxication, enterotoxism, intestinal intoxication, self-poisoning. (05 Mar 2000) |
| intoxication | <pharmacology> Poisoning, the state of being poisoned. Origin: Gr. Toxikon = poison (18 Nov 1997) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| activity, drug | A measure of the physiological response a drug produces in the body. A less active drug produces less response (and visa versa). (12 Dec 1998) |
| addictive drug | Any drug that creates a certain degree of euphoria and has a strong potential for addiction. (05 Mar 2000) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |