| downgrading r. |
a lepra reaction, similar in appearance to the reversal (“upgrading”) reaction, representing a deterioration in the immune response to Mycobacterium leprae with worsening of the clinical symptoms of leprosy and an increased index of M. leprae in the tissues; it may be seen during antileprosy treatment in those in whom M. leprae has become drug resistant or in those with poor compliance with the chemotherapeutic regimen.
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