| diffuse | Not definitely limited or localised, widely distributed. Origin: L. Dis = apart, fundere = to pour (18 Nov 1997) |
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| diffuse abdominal calcification | <radiology> Ovarian cystadenocarcinoma (psammomatous Calcium), pseudomyxoma peritonei, pseudomucinous cystadenoma of ovary, mucocele of appendix, undifferentiated abdominal malignancy, TB peritonitis, oil granulomata, meconium peritonitis (12 Dec 1998) |
| diffuse abscess | A collection of pus not circumscribed by a well-defined capsule. (05 Mar 2000) |
| diffuse aneurysm | An aneurysm that has enlarged and spread to the surrounding tissues in consequence of rupture of its walls. Synonym: consecutive aneurysm. (05 Mar 2000) |
| diffuse angiokeratoma | <disease> Lysosomal storage disease caused by a deficiency of alpha-galactosidase a and resulting in an accumulation of globotriaosylceramide in the renal and cardiovascular systems. The disease is characterised by telangiectatic skin lesions, renal failure, and disturbances of the cardiovascular, gastrointestinal, and central nervous systems. Inheritance: x-linked. (08 Mar 2000) |
| diffuse arterial ectasia | Spontaneous enlargement with dilation of the vessels in a circumscribed area. (05 Mar 2000) |
| diffuse brain atrophy | A form of dementia caused by destruction (atrophy) of the frontal lobes of the brain. This condition leads to the progressive deterioration of mental functioning. Incidence: 9 in 10,000 people in the general population. (27 Sep 1997) |
| diffuse choroiditis | A widespread exudative inflammation of the choroid, with progressive resolution of older lesions as new ones occur. (05 Mar 2000) |
| diffuse cutaneous leishmaniasis | Leishmaniasis caused by several New and Old World species and strains of Leishmania (L. Mexicana amazonensis, L. M. Pifanoi, possibly L. M. Garnhami and L. M. Venezuelensis; in Ethiopia, L. Aethiopica, and unidentified leishmanial agents in Namibia and Tanzania). The condition is associated with a suppressed cell-mediated immune response, so that the non-ulcerating, non-necrotizing cutaneous lesions can spread widely over the body; great numbers of parasite-filled macrophages are found in the dermal lesions. Healing does not appear to occur unless an acquired cellular hypersensitivity can develop. Synonym: anergic leishmaniasis, diffuse leishmaniasis, disseminated cutaneous leishmaniasis, leishmaniasis tegumentaria diffusa, pseudolepromatous leishmaniasis. (05 Mar 2000) |
| diffuse cutaneous mastocytosis | A benign process consisting of focal cutaneous infiltrates composed of mast cells; lesions are flat or slightly elevated, form wheals and itch when stroked; bone lesions may occur. Synonym: urticaria pigmentosa. (05 Mar 2000) |
| diffuse deep keratitis | An inflammation of the posterior corneal stroma. Synonym: diffuse deep keratitis. (05 Mar 2000) |
| diffuse emphysema | Emphysema affecting all parts of the lobules, in part, or usually the whole, of the lungs, and usually associated with a1-antiprotease deficiency emphysema. Synonym: diffuse emphysema, generalised emphysema, panacinar emphysema. (05 Mar 2000) |
| diffuse gallbladder wall thickening | <radiology> Criterion: gall bladder wall greater than 3 mm may appear thicker due to surrounding ascites, cholecystitis (acute or chronic), non-fasting state, chronic hypoalbuminaemia, hepatitis, congestive heart failure, fat in gall bladder fossa Cf: focal thickening (12 Dec 1998) |
| diffuse ganglion | A cystic swelling due to inflammatory effusion into one or several adjacent tendon sheaths. (05 Mar 2000) |
| diffuse glomerulonephritis | Glomerulonephritis affecting most of the renal glomeruli; it may lead to azotemia. (05 Mar 2000) |
| cerebral sclerosis, diffuse | Diffuse progressive degeneration of the white matter of the brain, accompanied by mental deterioration, severe motor disturbances, and early death. (12 Dec 1998) |
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| goiter, diffuse toxic | Graves' disease, the most common cause of hyperthroidism, too much thyroid hormone. (12 Dec 1998) |
| chronic diffuse sclerosing osteomyelitis | A proliferative reaction of bone to a low-grade infection of the jaws; most often seen in middle-aged or older black women as extensive, often bilateral radio-opacities of the mandible and maxilla. (05 Mar 2000) |
| hyperostosis, diffuse idiopathic skeletal | A disease of elderly men characterised by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions. (12 Dec 1998) |
| oesophageal spasm, diffuse | A motor disorder of the oesophagus characterised by chest pain and dysphagia. Pathogenesis is unclear. Strong, nonpropulsive contractions of the oesophagus evoked by deglutition occur, especially in the elderly. (12 Dec 1998) |
| keratoderma, palmoplantar, diffuse | An autosomal dominant disorder characterised by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (keratoderma, palmoplantar), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present. (12 Dec 1998) |
| leishmaniasis, diffuse cutaneous | A form of leishmaniasis, cutaneous caused by leishmania aethiopica in ethiopia and kenya, l. Pifanoi in venezuela, l. Braziliensis in south america, and l. Mexicana in central america. This disease is characterised by massive dissemination of skin lesions without visceral involvement. (12 Dec 1998) |
| leukodystrophy with diffuse Rosenthal fibre formation | A metabolic disorder whose onset can be in infancy, adolescence, or adulthood; characterised pathologically by widespread cerebral demyelination with astrocyte and primitive oligodendroglial cell proliferation; refractile Rosenthal fibres result from the degeneration of these proliferating cells; aetiology unknown, but possibly due to a metabolic defect of astrocytes; sex-linked recessive disorder. (05 Mar 2000) |
| lymphoma, diffuse | Malignant lymphoma in which neoplastic cells diffusely infiltrate the entire lymph node without any definite organised pattern. Patients whose lymphomas present a diffuse pattern generally have a more unfavorable survival outlook than those presenting with a follicular or nodular pattern. (12 Dec 1998) |
| lymphoma, large-cell, diffuse | Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (12 Dec 1998) |
| lymphoma, mixed-cell, diffuse | A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases. (12 Dec 1998) |
| lymphoma, small cleaved-cell, diffuse | An intermediate-grade malignant lymphoma in which the neoplastic cells (B-lymphocytes) exhibit variability in size, configuration, and degree of differentiation. The cells have distinctive nuclei, irregular in shape, with marked indentations and angularity. (12 Dec 1998) |