| antigens, differentiation | Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation. (12 Dec 1998) |
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| antigens, differentiation, b-lymphocyte | Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumours of B-cell origin. (12 Dec 1998) |
| antigens, differentiation, myelomonocytic | Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukaemias and lymphomas. (12 Dec 1998) |
| antigens, differentiation, t-lymphocyte | Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function. (12 Dec 1998) |
| B-cell differentiation/growth factors | Various substances, usually obtained from the supernatant of T-cell cultures, such as interleukin 4, 5, and 6. These substances are necessary for B-cell growth, maturation, and differentiation into plasma cells or B memory cells. (05 Mar 2000) |
| cell differentiation | Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialised cells, tissues, and organs. (12 Dec 1998) |
| cluster of differentiation | Cell membrane molecules that are used to classify leukocytes into subsets. CD molecules are classified by monoclonal antibodies. (05 Mar 2000) |
| cluster of differentiation 2 | A glycoprotein that is expressed on all peripheral T-cells, large granular lymphocytes and most, but not all, thymocytes. CD2 is involved in signal transduction and cell adhesion. (05 Mar 2000) |
| cluster of differentiation 3 | A complex of 5 polypeptides associated with the T-cell receptor and is involved in signal transduction. (05 Mar 2000) |
| cluster of differentiation 4 | A glycoprotein found on various subsets of T-cells, i.e., usually no helper and some T cytotoxic cells. (05 Mar 2000) |
| cluster of differentiation 8 | Membrane glycoprotein found on subsets of T lymphocytes. CD8 is expressed on T cytotoxic cells and T suppressor cells. Acronym: CD (05 Mar 2000) |
| correlative differentiation | Differentiation due to the interaction of different parts of an organism. (05 Mar 2000) |
| self-differentiation | Differentiation resulting from the action of intrinsic causes. (05 Mar 2000) |
| sex differentiation | Differentiation of male and female tissues and organs during embryogenesis, but after sex determination (sex determination (genetic)). (12 Dec 1998) |
| sex differentiation disorders | Disorders in the differentiation process of gonadal tissues and organs during embryogenesis. (12 Dec 1998) |