| deoxyribonuclease | <enzyme> An endonuclease with preference for DNA. Pancreatic DNAse I yields di and oligo nucleotide 5_ phosphates, pancreatic DNAse II yields 3_ phosphates. In chromatin, the sensitivity of DNA to digestion by DNAse I depends on its state of organisation, transcriptionally active genes being much more sensitive than inactive genes. Acronym: DNAase (10 Nov 1998) |
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| deoxyribonuclease bamhi | <enzyme> One of the type II site-specific deoxyribonucleases (ec 3.1.21.4). It recognises and cleaves the sequence g/gatcc at the slash. Bamhi is from bacillus amyloliquefaciens n. Numerous isoschizomers have been identified. Registry number: EC 3.1.21.- (12 Dec 1998) |
| deoxyribonuclease ecori | <enzyme> One of the type II site-specific deoxyribonucleases (ec 3.1.21.4). It recognises and cleaves the sequence g/aattc at the slash. Ecori is from e coliry13. Several isoschizomers have been identified. Registry number: EC 3.1.21.- (12 Dec 1998) |
| deoxyribonuclease hindiii | <enzyme> One of the type II site-specific deoxyribonucleases (ec 3.1.21.4). It recognises and cleaves the sequence a/agctt at the slash. Hindiii is from haemophilus influenzae r(d). Numerous isoschizomers have been identified. Registry number: EC 3.1.21.- (12 Dec 1998) |
| deoxyribonuclease hpaii | <enzyme> One of the type II site-specific deoxyribonucleases (ec 3.1.21.4). It recognises and cleaves the sequences c/cgg and ggc/c at the slash. Hpaii is from haemophilus parainfluenzae. Several isoschizomers have been identified. Registry number: EC 3.1.21.- (12 Dec 1998) |
| deoxyribonuclease I | <enzyme> An enzyme capable of hydrolyzing highly polymerised DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyses endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA. Registry number: EC 3.1.21.1 (12 Dec 1998) |
| deoxyribonuclease II | An endonuclease that cleaves both strands of native DNA (as well as single-stranded DNA) to produce a mixture of oligodeoxynucleotides, each ending in a 3'-phosphate. Synonym: acid deoxyribonuclease. (05 Mar 2000) |
| deoxyribonuclease S1 | <enzyme> An enzyme cleaving RNA or DNA to 5'-ended mono-or oligonucleotides; prefers single stranded polynucleic acids. Synonym: deoxyribonuclease S1. (05 Mar 2000) |
| deoxyribonucleases | <enzyme> Enzymes which catalyze the hydrolases of ester bonds within DNA. Registry number: EC 3.1.- (12 Dec 1998) |
| deoxyribonucleases, type I site-specific | <enzyme> Enzyme systems containing three different subunits and requiring ATP, s-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent atpases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognise specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.3 (12 Dec 1998) |
| deoxyribonucleases, type II site-specific | <enzyme> Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognise specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.4 (12 Dec 1998) |
| deoxyribonucleases, type III site-specific | <enzyme> Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as atpases. They exist as complexes with modification methylases of similar specificity. The systems recognise specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.5 (12 Dec 1998) |
| acid deoxyribonuclease | An endonuclease that cleaves both strands of native DNA (as well as single-stranded DNA) to produce a mixture of oligodeoxynucleotides, each ending in a 3'-phosphate. Synonym: acid deoxyribonuclease. (05 Mar 2000) |
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| pancreatic deoxyribonuclease | <enzyme> An enzyme capable of hydrolyzing highly polymerised DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyses endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA. Registry number: EC 3.1.21.1 (12 Dec 1998) |
| caspase-activated deoxyribonuclease | <enzyme> Degrades DNA during apoptosis, inhibited by icad (inhibitor of cad); a protein of 343 amino acids carrying a nuclear localization signal. Registry number: EC 3.1.- Synonym: cad enzyme, caspase-activated dnase (26 Jun 1999) |
| spleen deoxyribonuclease | Former name for micrococcal endonuclease. (05 Mar 2000) |
| novel human deoxyribonuclease | <enzyme> 45% identical to dnase i. Registry number: EC 3.1.- Synonym: nhdnase (26 Jun 1999) |