| cyclin | <protein> Proteins (A and B forms known) whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are though to drive cells into G2 phase and thus to mitosis. Cyclins combine with p34 kinase (cdc2) to form maturation-promoting factor (MPF). See: M phase promoting factor. (18 Nov 1997) |
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| cyclin a | A 33-kD protein identical to adenovirus e1a-associated protein p60. Cyclin a regulates p33cdk2 and p34cdc2, and is necessary for progression through the s phase of the cell cycle. (12 Dec 1998) |
| cyclin b | A 58-kD protein that is regulated post-transcriptionally and post-translationally in the cell cycle. (12 Dec 1998) |
| cyclin d1 | Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin d1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms. (12 Dec 1998) |
| cyclin e | A 50-kD protein that complexes with cdk2 in the late g1 phase of the cell cycle. (12 Dec 1998) |
| cyclin E-dependent kinase | <chemical> Synonym: cyce-h1k, cyce-dependent h1 kinase (26 Jun 1999) |
| cyclin-dependent kinases | Protein kinases that control cell cycle progression in all eukaryotes and require physical association with cyclins to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (12 Dec 1998) |
| cyclins | Regulatory proteins that function in the cell cycle to activate maturation-promoting factor. They complex with p34cdc2 (protein p34cdc2), the catalytic subunit of maturation-promoting factor, and modulate its protein kinase activity. Cyclins themselves have no enzymatic activity. (12 Dec 1998) |
| GAK, cyclin G-associated kinase | <chemical> Has a ser/thr protein kinase-like catalytic domain at the n-terminal; contains a tensin/auxilin-like domain; genbank d38560 Synonym: gak protein (26 Jun 1999) |
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