| KW change | Keith Wagener change |
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| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
| SSCP | single-stranded conformational polymorphism |
| MCD | 1) Minimal Change Disease 2) Menstrual Cycle Day |
| MCL | Minimal Change Disease |
| SSCP | PCR)-single stand conformational polymorphism |
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| PCR-SSCP | Polymerase chain reaction single strand conformational polymorphism |
| SSCP | Single Strand Conformational Polymorphism |
| SSCP | Single Strand Conformational Polymorphism analysis |
| SSCP | Single Stranded Conformational Polymorphism |
| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
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| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
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| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
| Haworth conformational formula | <biochemistry> Of cyclic sugars, for the pyranoses, these depict those shapes (conformations) on which none, one, or two ring-atoms lie outside the plane of the ring. If there are two such atoms para to each other, they can lie 1) on opposite sides of the plane (trans), giving chair forms, or 2) on the same side of the plane (cis), giving boat forms. For beta-d-ribopyranose, the two chair forms (4C1 and 1C4) are depicted. Similarly, there are six boat conformations. If the two (trans) exoplanar atoms are meta to each other, the conformation is a skew form; if the two atoms are ortho to each other, the conformation is a half-chair form. For the furanoses, the envelope conformations have one ring-atom exoplanar. If there are three adjacent, coplanar ring-atoms (the two exoplanar ring-atoms on opposite sides of the plane), the conformations are twist forms. (05 Mar 2000) |
| single stranded conformational polymorphism | Technique for detecting point mutations in genes by amplifying a region of genomic DNA (using asymmetric PCR) and running the resulting product on a high quality gel. Single base substitutions can alter the secondary structure of the fragment in the gel, producing a visible shift in its mobility. (18 Nov 1997) |
| Armanni-Ebstein change | Glycogen vacuolization of the loops of Henle, seen in diabetics before the introduction of insulin. Synonym: Armanni-Ebstein change. (05 Mar 2000) |
| Baggenstoss change | Distention of pancreatic acini by proteinaceous secretion, seen in dehydration. (05 Mar 2000) |
| change | An alteration; in pathology, structural alteration of which the cause and significance is uncertain. Synonym: shift. (05 Mar 2000) |
| change of life | Colloquialism for menopause, climacteric. (05 Mar 2000) |
| chemical change | A process in which one or more substances are changed into one or more different substances. (09 Oct 1997) |
| minimal-change disease | <nephrology> A disorder of the kidneys which largely affects the glomerulus, the blood filtering structure. This disorder is one common cause of nephrotic syndrome, minimal glomerular changes, in children affecting 2 to 3 children per 100,000 population under age 16 in the USA. Minimal change disease is also seen rarely in adults. The cause is unknown but may be related to an autoimmune illness. It is marked by oedema, albuminuria, and an increase in cholesterol in the blood, but otherwise with fairly good renal function. Tubular epithelium is vacuolated by cholesterol droplets, but the glomeruli show only that the foot processes of the glomerular epithelial cells are fused, probably secondary to the proteinuria; the cause of the increased glomerular permeability to plasma protein is unknown. Risk factors include a history for a immune disorder, recent immunisation or a bee sting. Diagnosis is made by renal biopsy. Treatment include systemic corticosteroids which are usually quite effective in curing this disease. Other medications include chlorambucil and cyclophosphamide. In most cases, a moderate protein diet (1 gram protein per Kg body weight per day) will be recommended. Salt (sodium) restriction can be helpful to reduce swelling and vitamin D is usually supplemented. Synonym: lipoid nephrosis (27 Sep 1997) |
| minimal-change nephrotic syndrome | <nephrology> A disorder of the kidneys which largely affects the glomerulus, the blood filtering structure. This disorder is one common cause of nephrotic syndrome, minimal glomerular changes, in children affecting 2 to 3 children per 100,000 population under age 16 in the USA. Minimal change disease is also seen rarely in adults. The cause is unknown but may be related to an autoimmune illness. It is marked by oedema, albuminuria, and an increase in cholesterol in the blood, but otherwise with fairly good renal function. Tubular epithelium is vacuolated by cholesterol droplets, but the glomeruli show only that the foot processes of the glomerular epithelial cells are fused, probably secondary to the proteinuria; the cause of the increased glomerular permeability to plasma protein is unknown. Risk factors include a history for a immune disorder, recent immunisation or a bee sting. Diagnosis is made by renal biopsy. Treatment include systemic corticosteroids which are usually quite effective in curing this disease. Other medications include chlorambucil and cyclophosphamide. In most cases, a moderate protein diet (1 gram protein per Kg body weight per day) will be recommended. Salt (sodium) restriction can be helpful to reduce swelling and vitamin D is usually supplemented. Synonym: lipoid nephrosis (27 Sep 1997) |
| Crooke's hyaline change | Replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogenous hyaline material; a characteristic finding in Cushing's syndrome, but usually not present in the cells of a basophil adenoma. Synonym: Crooke's hyaline degeneration. (05 Mar 2000) |
| social change | Social process whereby the values, attitudes, or institutions of society, such as education, family, religion, and industry become modified. It includes both the natural process and action programs initiated by members of the community. (12 Dec 1998) |
| enthalpy change | <chemistry> In a reaction, this is more or less equal to the difference between the energy put into breaking bonds and the enery gained from new bond formation. (13 Oct 1997) |
| epigenetic change | <biology> Any changes in an organism brought about by alterations in the action of genes are called epigenetic changes. Epigenetic transformation refers to those processes which cause normal cells to become tumour cells without the occurrence of any mutations. (07 May 1998) |
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