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coloboma of optic disk coloboma of optic nerve, 1. a coloboma, mild or severe, within or at the optic nerve head. A mild coloboma may be a separate, isolated entity, unilateral, and limited to minor cupping in the optic disk. A severe coloboma may be part of a bridge coloboma or part of a complete coloboma, or it may enlarge the optic disk two to four times and thus affect the adjacent retina and choroid. Nystagmus, strabismus, severe impairment of vision, microphthalmia, cyclopia, and anencephaly may be present. ...
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