| colla | Plural of collum. (05 Mar 2000) |
|---|---|
| collacin | Degenerated collagen. Synonym: collastin. (05 Mar 2000) |
| collagen | <protein> The protein substance of the white fibres (collagenous fibres) of skin, tendon, bone, cartilage and all other connective tissue, composed of molecules of tropocollagen, it is converted into gelatin by boiling. Collagenous pertaining to collagen, forming or producing collagen. Origin: Gr. Kolla = glue, gennan = to produce (18 Nov 1997) |
| collagen diseases | Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (12 Dec 1998) |
| collagen fibre | An individual fibre that varies in diameter from less than 1 um to about 12 um and is composed of fibrils; the fibre's, which are usually arranged in bundles, undergo some branching and are of indefinite length; chemically the fibre is a glycoprotein, collagen, which yields gelatin upon boiling; they make up the principal element of irregular connective tissue, tendons, aponeuroses, and most ligaments, and occur in the matrix of cartilage and osseous tissue. Synonym: white fibre. (05 Mar 2000) |
| collagen fibrils | The fibril's that comprise a collagen fibre, ranging from 20 to 200 nm and averaging about 100 nm in diameter (substantially larger in tendons), with cross-striations averaging 64 nm. Synonym: collagen fibrils. (05 Mar 2000) |
| collagen injection | Correction of superficial soft tissue deformities, acne scars, or age-related skin changes by injection (implantation) of collagen; bovine collagen preparations are commonly used. Prior intradermal testing is necessary to exclude hypersensitivity. (05 Mar 2000) |
| collagen telopeptidase | <enzyme> Neutral metalloproteinase from porcine gingiva; removes the extra-helical extension peptides proximal to the lysyl residue at position 17 Registry number: EC 3.4.24.- Synonym: collagen depolymerase (26 Jun 1999) |
| collagen-vascular diseases | A group of generalised disease's affecting connective tissue and frequently characterised by fibrinoid necrosis or vasculitis; in some collagen disease's, auto-immunization, particularly antinuclear antibodies, has been shown and circulating immune complexes are found. The term is not entirely acceptable because there is no evidence that collagen is primarily involved; "collagen" was once synonymous with "connective tissue" rather than describing a specific fibrinous protein in that tissue. See: connective-tissue diseases. (05 Mar 2000) |
| collagenase | <enzyme> Proteolytic enzyme capable of breaking native collagen. Once the initial cleavage is made, less specific proteases will complete the degradation. Collagenases from mammalian cells are metallo enzymes and are collagen type specific. May be released in latent (proenzyme) form into tissues and require activation by other proteases before they will degrade fibrillar matrix. Bacterial collagenases are used in tissue disruption for cell harvesting. (18 Nov 1997) |
| collagenase A | <enzyme> An enzyme that catalyses the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. Synonym: clostridiopeptidase A, collagenase A, collagenase I. (05 Mar 2000) |
| collagenases | <enzyme> Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. Registry number: EC 3.4.24.- (12 Dec 1998) |
| collagenation | 1. Replacement of tissues or fibrin by collagen. 2. Synthesis of collagen by fibroblasts. Synonym: collagenation. (05 Mar 2000) |
| collagenic | Producing or containing collagen. Synonym: collagenic. (05 Mar 2000) |
| collagenization | 1. Replacement of tissues or fibrin by collagen. 2. Synthesis of collagen by fibroblasts. Synonym: collagenation. (05 Mar 2000) |