| chronic granulomatous d. |
any of a group of immunodeficiencies of X-linked or autosomal recessive inheritance, caused by failure of the respiratory or metabolic burst, resulting in deficient microbicidal ability. The clinical picture consists of frequent, severe, prolonged bacterial and fungal infections of the skin, oral and intestinal mucosa, reticuloendothelial system, bones, lungs, and genitourinary tract. The course of the disease varies: symptoms may appear in the neonate, with death during the first decade, or a patient may survive into middle age. There seem to be no physiologic differences between the X-linked and the autosomal recessive types.
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