| chimeric molecule | A molecule (usually a biopolymer) containing sequences derived from two different genes; specifically, from two different species. Compare: chimera. (05 Mar 2000) |
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| chimeric | 1. Relating to a chimera. Compare: chimera, chimeric molecule. 2. Composed of parts that are of different origin and are seemingly incompatible. (05 Mar 2000) |
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| chimeric antibodies | Antibodies that may have the FAB fragment from one species fused with FC fragment from another. (05 Mar 2000) |
| chimeric antibody | <immunology> An antibody that contains polypeptides from different species. (05 Jan 1998) |
| chimeric DNA | <molecular biology> A molecule of DNA that has resulted from recombination, or has resulted from DNA from two sources being spliced together. (05 Jan 1998) |
| chimeric/humanised antibody | <immunology> Genetically engineered combination of a human and mouse antibody. Because a monoclonal antibody is always made with mice cells, it causes an immune response when injected into humans. By replacing the constant regions of a mouse antibody with those of a human antibody, an antibody that binds to an antigen like the original monoclonal antibody, but which is recognised by the human immune system like a human protein, can be manufactured. Alternatively, only those amino acids directly involved in antigen binding are transferred from the mouse antibody into the framework of the human antibody, with a similar result. (05 Jan 1998) |
| chimeric proteins | Proteins in individuals that are derived from genetically different zygotes. (12 Dec 1998) |
| vascular cell adhesion molecule-1 | Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (12 Dec 1998) |
| cell adhesion molecule | <molecular biology> Although this could mean any molecule involved in cellular adhesive phenomena, it has acquired a more restricted sense, namely a molecule on the surface of animal tissue cells, antibodies (or Fab fragments) against that specifically inhibit some form of intercellular adhesion. Examples are Liver Cell Adhesion Molecule and Neural Cell Adhesion Molecule, both named from tissues in which first detected, although their occurrence is not in fact restricted to these. Acronym: CAM (26 Nov 1998) |
| repellant guiding molecule | <cell biology> Specific molecules that inhibit the activity of growth cones and are thought to be important in establishing axon pathways during nervous system development. See: growth cone collapse. (18 Nov 1997) |
| gram-molecule | <unit> The amount of a substance with a mass in grams equal to its molecular weight; e.g., a gram-molecule of hydrogen weighs 2.016 g, that of water 18.015 g. (05 Mar 2000) |
| molecule | <chemistry> The result of two or more atoms combining by chemical bonding. (09 Oct 1997) |
| hybrid molecule | <molecular biology> A double-stranded nucleic acid molecule which was artificially created from two different single-stranded nucleic acid molecules from different sources, for the purpose of comparing their nucleotide sequences. (09 Oct 1997) |
| hydrophilic signaling molecule | <molecular biology> A type of molecule which, because it is easily dissolved in water (it is hydrophilic), can easily move through cell membranes and thus can be secreted from one cell and move into a target cell where it triggers a particular event. Many hormones and growth factors are hydrophilic signaling molecules. (09 Oct 1997) |
| neural cell adhesion molecule | See: NCAM. (18 Nov 1997) |
| intercellular adhesion molecule | See: ICAM. (18 Nov 1997) |