| chimeric | 1. Relating to a chimera. Compare: chimera, chimeric molecule. 2. Composed of parts that are of different origin and are seemingly incompatible. (05 Mar 2000) |
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| chimeric antibodies | Antibodies that may have the FAB fragment from one species fused with FC fragment from another. (05 Mar 2000) |
| chimeric antibody | <immunology> An antibody that contains polypeptides from different species. (05 Jan 1998) |
| chimeric DNA | <molecular biology> A molecule of DNA that has resulted from recombination, or has resulted from DNA from two sources being spliced together. (05 Jan 1998) |
| chimeric molecule | A molecule (usually a biopolymer) containing sequences derived from two different genes; specifically, from two different species. Compare: chimera. (05 Mar 2000) |
| chimeric proteins | Proteins in individuals that are derived from genetically different zygotes. (12 Dec 1998) |
| chimeric/humanised antibody | <immunology> Genetically engineered combination of a human and mouse antibody. Because a monoclonal antibody is always made with mice cells, it causes an immune response when injected into humans. By replacing the constant regions of a mouse antibody with those of a human antibody, an antibody that binds to an antigen like the original monoclonal antibody, but which is recognised by the human immune system like a human protein, can be manufactured. Alternatively, only those amino acids directly involved in antigen binding are transferred from the mouse antibody into the framework of the human antibody, with a similar result. (05 Jan 1998) |