| cell line, transformed | Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumour. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals. (12 Dec 1998) |
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| virus-transformed cell | A cell that has been genetically changed to a tumour cell, the change being subsequently tramsmitted to all descendent cell's; cell's transformed by oncornaviruses continue to produce virus in high concentration without being killed; DNA tumour virus-transformed cell's develop (along with other changes) tumour-associated antigens and rarely produce virus. (05 Mar 2000) |
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| transformed cell | <chemistry> The change of form or structure, conversion from one form to another. <oncology> The change that a normal cell undergoes as it becomes malignant. In eukaryotes, the conversion of normal cells to malignant cells in cell culture. Origin: L. Formatio = formation (18 Nov 1997) |
| transformed lymphocyte | See: lymphocyte transformation. (05 Mar 2000) |
| cell line | <cell culture> A cell line is a permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space. Lines differ from cell strains in that they have escaped the Hayflick limit and become immortalised. Some species, particularly rodents, give rise to lines relatively easily, whereas other species do not. No cell lines have been produced from avian tissues and the establishment of cell lines from human tissue is difficult. Many cell biologists would consider that a cell line is by definition already abnormal and that it is on the way towards becoming the culture equivalent of a neoplastic cell. (26 Mar 1998) |
| cell line rights | <cell culture> Ownership of a new organism entity. Rulings indicate that any organism that is patentable at all can be patented if it has been manipulated to do something useful. Usually, the rights do not reside with the individual who has supplied the source of the organism, but with the individual or organisation who has made it. (26 Mar 1998) |
| established cell line | <cell culture> A cell line is a permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space. Lines differ from cell strains in that they have escaped the Hayflick limit and become immortalised. Some species, particularly rodents, give rise to lines relatively easily, whereas other species do not. No cell lines have been produced from avian tissues and the establishment of cell lines from human tissue is difficult. Many cell biologists would consider that a cell line is by definition already abnormal and that it is on the way towards becoming the culture equivalent of a neoplastic cell. (26 Mar 1998) |
| T-cell-rich, B-cell lymphoma | <tumour> A B-cell lymphoma in which more than 90% of the cells are of T-cell origin, masking the large cells that form the neoplastic B-cell component. See: adult T-cell lymphoma. (05 Mar 2000) |
| alveolonasal line | A line connecting the alveolar point and the nasion. (05 Mar 2000) |
| Amberg's lateral sinus line | A line dividing the angle formed by the anterior edge of the mastoid process and the temporal line. (05 Mar 2000) |
| anocutaneous line | The line between the simple columnar epithelium of the rectum and the stratified epithelium of the anal canal. Synonym: linea anocutanea, anocutaneous line, dentate line. (05 Mar 2000) |
| anterior axillary line | A vertical line extending inferiorly from the anterior axillary fold. Synonym: linea axillaris anterior, linea preaxillaris, preaxillary line. (05 Mar 2000) |
| anterior junction line | Radiographic projection of the mediastinal tissue septum between the upper lobes behind the sternum. (05 Mar 2000) |
| anterior median line | The line of intersection of the midsagittal plane with the anterior surface of the body. Synonym: linea mediana anterior. (05 Mar 2000) |
| arcuate line | An arching or bow-shaped line. See: arcuate line of ilium, arcuate line of rectus sheath. Synonym: linea arcuata. (05 Mar 2000) |
| arcuate line of ilium | The iliac portion of the linea terminalis of the bony pelvis. Synonym: linea arcuata ossis ilii. (05 Mar 2000) |