| C5 c. |
an enzyme that splits the complement component C5 to C5a and C5b; the classical pathway C5 convertase is C4b,2a,3b; the alternative pathway C5 convertases are C3bn,Bb and C3bn,P,Bb; see under complement.
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| C5b,6 |
the hydrophilic complex of C5b and C6 formed in the initial steps of formation of the membrane attack complex; it is loosely associated with the membrane until it is bound by C7.
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| C5b,6,7 |
a trimolecular complex of C5b, C6, and C7 that binds to cell membranes in the formation of the membrane attack complex; it can be inhibited by binding by vitronectin, which yields an inactivated complex unable to bind to membranes. C5b,6,7 is also a chemotactic factor for neutrophils. Sometimes abbreviated C5b–7.
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| C5b,6,7,8 |
a complex generated by binding of C8 to membrane-bound C5b,6,7; it causes a slow leakage of the cell membrane. Sometimes abbreviated C5b–8.
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| C5b,6,7,8,9 |
the complete membrane attack complex (cytolytic agent) of the complement system, generated by addition of multiple molecules of C9 to C5b,6,7,8; this complex has a hydrophilic center that allows the rapid passage of water and ions through the cell membrane, causing osmotic lysis of the cell. Sometimes abbreviated C5b–9 or C5b–9n.
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