| reunion | One of the indian ocean islands, east of madagascar. Its capital is saint-denis. It was discovered in 1507 by the portuguese and claimed by france in 1638. It was first colonised in 1662 as isle de bourbon but renamed reunion in 1793. In 1946 it was made an overseas department of france. The name commemorates the reunion of the revolutionaries from marseilles with the national guard in paris in 1792. (12 Dec 1998) |
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| chromosome breakage | A type of chromosomal aberration which may result from spontaneous or induced breakage. Alkylating agents, various types of irradiation, and chemical mutagens have been found to cause induced chromosomal breakage. Breakage can induce base pair translocations, deletions, or chromatid breakage. (12 Dec 1998) |
| lock-and-key model | A model used to suggest the mode of operation of an enzyme in which the substrate fits into the active site of the protein like a key into a lock. (05 Mar 2000) |
| Adair-Koshland-Nemethy-Filmer model | <biochemistry, chemistry> A model to explain the allosteric form of cooperativity; in this model, in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits. Synonym: Adair-Koshland-Nemethy-Filmer model, induced fit model. (05 Mar 2000) |
| additive model | A model in which the combined effect of several factors is the sum of the effects that would be produced by each of the factors in the absence of the others. (05 Mar 2000) |
| age-structured model | <epidemiology> A mathematical model which take into consideration the division of the host population into different age classes. Such models can used to consider the consequences of such factors as age-dependent infection, morbidity or mortality rates or of age-specific vaccination schedules. (05 Dec 1998) |
| animal model | Study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable to those that occur in human populations. (05 Mar 2000) |
| Bingham model | A model representing the flow behaviour of a Bingham plastic, in the idealised case. (05 Mar 2000) |
| biomedical model | A conceptual model of illness that excludes psychological and social factors and includes only biological factors in an attempt to understand a person's medical illness or disorder. (05 Mar 2000) |
| biopsychosocial model | A conceptual model that assumes that psychological and social factors must also be included along with the biological in understanding a person's medical illness or disorder. (05 Mar 2000) |
| genetic model | A formalised conjecture about the behaviour of a heritable structure in which the component terms are intended to have literal interpretation as standard structures of empirical genetics. (05 Mar 2000) |
| mathematical model | <epidemiology> A formal framework to convey ideas about the components of a host-parasite interaction. Construction requires three major types of information: (a) a clear understanding of the interaction within the individual host between the infectious agent and the host, (b) the mode and rate of transmission between individuals, and (c) host population characteristics such as demography and behaviour. Mathematical models can aid exploration of the behaviour of the system under various conditions from which to determine the dominant factors generating observed patterns and phenomena. They also aid data collection and interpretation and parameter estimation, and provide tools for identifying possible approaches to control and for assessing the potential impact of different intervention measures. (05 Dec 1998) |
| catalytic model | <epidemiology> A (rather misleading name for a) type of compartmental model in which the force of infection is treated as a parameter to be estimated. (05 Dec 1998) |
| pathological model | An animal or animal stock that by inheritance or by artificial manipulation develops a disorder similar to some disease of interest and hence directly or by analogy furnishes evidence of its pathogenesis and may be used as a model for the study of preventive or therapeutic measures. (05 Mar 2000) |
| medical model | A set of assumptions that views behavioural abnormalities in the same framework as physical disease or abnormalities. (05 Mar 2000) |