BRCA1 Protein - ț̢
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Synonyms : Breast Cancer 1 Protein
BRCA2 Protein - ț̢
A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Synonyms : BRCA2 Gene Product, Breast Cancer 2 Protein, FANCD1 Protein, Fanconi Anemia Group D1 Complementing Protein, Fanconi Anemia Group D1 Protein