| botulin | <protein> A very strong poison which affects the nervous system, made by the bacteria Clostridium botulinum. The poison causes the food poisoning known as botulism. (09 Oct 1997) |
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| botulinogenic | Botulism-producing. Synonym: botulinogenic. (05 Mar 2000) |
| botulinum antitoxin | An equine antitoxin against the toxins produced by the type a, b, or e strain of clostridium botulinum. Generally trivalent (abe) antitoxin is used. (12 Dec 1998) |
| botulinum toxin | <protein> Neurotoxin (50 kD, 7 distinct serotypes) produced by certain strains of Clostridium botulinum. The bacterium produces the toxin as a complex with a haemagglutinin that prevents toxin inactivation in the gut. Proteolysis in the body results in cleavage into two fragments A and B. B binds to gangliosides and may stimulate the endocytosis of fragment A. See: synaptobrevin, tetanus toxin. (18 Nov 1997) |
| botulinum toxin type a | <chemical> A neurotoxin produced by clostridium botulinum. When consumed in contaminated food it can cause paralysis and death. In its purified form, it has been used in the treatment of blepharospasm and strabismus. Pharmacological action: neuromuscular agents. (12 Dec 1998) |
| botulinum toxins | <chemical> Toxins produced by clostridium botulinum. There are at least seven different substances, most being proteins. They have neuro-, entero-, and haemotoxic properties, are immunogenic, and include the most potent poisons known. The most commonly used apparently blocks release of acetylcholine at cholinergic synapses. Pharmacological action: anti-dyskinesia agents. (12 Dec 1998) |
| botulinus toxin | A potent neurotoxin from Clostridium botulinum. Synonym: botulin, botulismotoxin. (05 Mar 2000) |