| bombesin | <endocrinology> Tetradecapeptide neurohormone with paracrine/autocrine effects first isolated from skin of fire bellied toad Bombina bombina), mammalian equivalent is gastrin-releasing peptide. Bombesin cross reacts with gastrin-releasing peptide receptors. Both are mitogenic for Swiss 3T3 fibroblasts at nanomolar levels. Neuropeptides of this type are found in many tissues and at high levels in pulmonary (small cell carcinoma) and thyroid tumours. (14 Mar 2000) |
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| receptors, bombesin | Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behaviour of cells. Gastrin- releasing peptide (grp), grp 18-27 (neuromedin c), and neuromedin b are endogenous ligands of bombesin receptors in mammals. (12 Dec 1998) |
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