| monocyte chemotactic and activating factor | Cytokine of the C C subfamily, co induced with IL-8 on stimulation of endothelial cells, fibroblasts or monocytes that activates and is chemotactic for, monocytes. A chemokine. (18 Nov 1997) |
|---|---|
| monocyte derived neutrophil chemotactic factor | <cytokine> A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4. Acronym: IL-8 (12 Dec 1998) |
| complement chemotactic factor | The activated complex of the fifth, sixth, and seventh components of complement (C567) which induces chemotaxis in the case of polymorphonuclear leukocytes. (05 Mar 2000) |
| eosinophil chemotactic factor of anaphylaxis | A peptide (MW 500 to 600) that is chemotactic for eosinophilic leukocytes and is released from disrupted mast cells. (05 Mar 2000) |
| adenoma, basophil | A small tumour of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of acth, resulting in cushing's syndrome. (12 Dec 1998) |
| basophil | <haematology> Mammalian granulocyte with large heterochromatic basophilic granules that contain histamine bound to a protein and heparin like mucopolysaccharide matrix. They are not phagocytic. Very similar to mast cells though it is not clear whether they have common lineage. (18 Nov 1997) |
| basophil adenoma | <tumour> A tumour of the adenohypophysis in which the cell cytoplasm stains with basic dyes, often ACTH producing. (05 Mar 2000) |
| basophil cell of anterior lobe of hypophysis | beta cell of anterior lobe of hypophysis |
| basophil degranulation test | An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured. (12 Dec 1998) |
| basophil granule | A granule that stains readily with a basic dye. (05 Mar 2000) |
| basophil substance | The material consisting of granular endoplasmic reticulum and ribosomes that occurs in nerve cell bodies and dendrites. Synonym: basophil substance, basophilic substance, chromophil substance, Nissl bodies, Nissl granules, substantia basophilia, tigroid bodies, tigroid substance. (05 Mar 2000) |
| tissue basophil | <cell biology, immunology> Resident cell of connective tissue that contains many granules rich in histamine and heparan sulphate. Release of histamine from mast cells is responsible for the immediate reddening of the skin in a weal and flare response. Very similar to basophils and possibly derived from the same stem cells. Two types of mast cells are now recognised, those from connective tissue and a distinct set of mucosal mast cells, the activities of the latter are T-cell dependent. (05 Jan 1998) |
| chemotactic | A response of motile cells or organisms in which the direction of movement is affected by the gradient of a diffusible substance. Differs from chemokinesis in that the gradient alters probability of motion in one direction only, rather than rate or frequency of random motion. (18 Nov 1997) |
| chemotactic factors | Chemical substances that attract or repel cells or organisms. The concept denotes especially those factors released as a result of tissue injury, invasion, or immunologic activity, that attract leukocytes, macrophages, or other cells to the site of infection or insult. (12 Dec 1998) |
| chemotactic factors, eosinophil | Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ecf-a, released mainly by mast cells. (12 Dec 1998) |