| anti-basement membrane antibody | Autoantibodies to renal glomerular basement membrane antigens. (05 Mar 2000) |
|---|---|
| anti-basement membrane glomerulonephritis | Glomerulonephritis resulting from anti-basement membrane antibodies, characterised by smooth linear deposits of IgG and C3 along glomerular capillary walls; includes rapidly progressive glomerulonephritis and glomerulonephritis in Goodpasture's syndrome. (05 Mar 2000) |
| anti-basement membrane nephritis | Glomerulonephritis produced by autologous or heterologous antibodies to the glomerular capillary basement membranes, the latter known as anti-kidney serum nephritis. (05 Mar 2000) |
| anti-glomerular basement membrane disease | Glomerulonephritis, usually of a generalised proliferative crescent-forming histologic type with a rapidly progressive course, marked by circulating anti-gbm antibodies and linear deposits of immunoglobulin and complement along the glomerular basement membrane. When associated with pulmonary haemorrhage the condition is called goodpasture syndrome. (12 Dec 1998) |
| basement membrane | <cell biology> Extracellular matrix characteristically found under epithelial cells. There are two distinct layers: the basal lamina, immediately adjacent to the cells, is a product of the epithelial cells themselves and contains collagen type IV and the reticular lamina is produced by fibroblasts of the underlying connective tissue and contains fibrillar collagen. (15 Nov 1997) |
| basement | The outer wall of the ground story of a building, or of a part of that story, when treated as a distinct substructure. (See Base, 3) Hence: The rooms of a ground floor, collectively. <anatomy> Basement membrane, a delicate membrane composed of a single layer of flat cells, forming the substratum upon which, in many organs, the epithelioid cells are disposed. Origin: F. Soubassement. Of uncertain origin. Cf. Base, Bastion. Source: Websters Dictionary (01 Mar 1998) |
| basement lamina | <cell biology> Extracellular matrix characteristically found under epithelial cells. There are two distinct layers: the basal lamina, immediately adjacent to the cells, is a product of the epithelial cells themselves and contains collagen type IV and the reticular lamina is produced by fibroblasts of the underlying connective tissue and contains fibrillar collagen. (15 Nov 1997) |
| adiposogenital dystrophy | A disorder characterised primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Visual loss, behavioural abnormalities, and diabetes insipidus may occur. Frohlich's syndrome often is used synonymously for this disorder, although the original case involved a pituitary tumour; most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms. Synonym: adiposis orchica, adiposogenital degeneration, adiposogenital dystrophy, adiposogenital syndrome, hypophysial syndrome, hypothalamic obesity with hypogonadism. Origin: L. Fr. G. Dys-, bad, + trophe, nourishment (05 Mar 2000) |
| adult pseudohypertrophic muscular dystrophy | Muscular dystrophy of late onset, often in the second or third decade, with relatively mild course; X-linked recessive inheritance; perhaps allelic with Duchenne's dystrophy, but milder and not a genetic lethal. Compare: Duchenne dystrophy. Synonym: Becker type tardive muscular dystrophy. (05 Mar 2000) |
| Barnes' dystrophy | A rare type of muscular dystrophy, in which muscles are often hypertrophic and stronger than normal, but later become weak and atrophic. (05 Mar 2000) |
| Becker's muscular dystrophy | An X-linked inherited disorder characterised by slowly progressive muscle weakness of the legs and pelvis. Other symptoms and findings include increased difficulty walking, intellectual retardation, fatigue and pseudohypertrophy of the calf muscles. (27 Sep 1997) |
| Becker type muscular dystrophy | A muscular dystrophy that has many of the clinical features of Duchenne muscular dystrophy e.g., symmetrical involvement of first the pelvicrural muscles and then the pectoral girdle and proximal upper extremity muscles; pseudohypertrophy, especially of the calf muscles but with a much later age of onset (35-45 years), and more benign course. X-linked inheritance. (05 Mar 2000) |
| Becker type tardive muscular dystrophy | Muscular dystrophy of late onset, often in the second or third decade, with relatively mild course; X-linked recessive inheritance; perhaps allelic with Duchenne's dystrophy, but milder and not a genetic lethal. Compare: Duchenne dystrophy. Synonym: Becker type tardive muscular dystrophy. (05 Mar 2000) |
| benign pseudohypertrophic muscular dystrophy | <neurology> An X-linked inherited disorder characterised by slowly progressive muscle weakness of the legs and pelvis. Other symptoms and findings include increased difficulty walking, intellectual retardation, fatigue and pseudohypertrophy of the calf muscles. (06 Aug 1998) |
| macular dystrophy | A group of disorders involving predominately the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the retina, retinal pigment epithelium, Bruch's membrane, choroid, or a combination of these tissues. See: Stargardt's disease, Best's disease. (05 Mar 2000) |