| atropine methonitrate | The methylnitrate of atropine, with the same actions and uses as atropine, but less lipid-soluble and hence with fewer central nervous system effects; a quaternary compound. (05 Mar 2000) |
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| atropine | <drug> A toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms. Pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and AV conduction. Uses: Treat bradycardia, asystole, and AV block Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects Atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 mL sterile water or normal saline. Potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium Note: The denervated heart will not respond to atropine. (15 Mar 2000) |
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| atropine dehydrase | <enzyme> Proposed mechanism for conversion of atropine or scopolamine to apoatropine or aposcopolamine via a mechanism using hydroxysteroid sulfotransferase by guinea pig liver Registry number: EC 2.8.2.- Synonym: scopolamine dehydrase (26 Jun 1999) |
| atropine derivatives | Analogs and derivatives of atropine. (12 Dec 1998) |
| atropine methylbromide | A quaternary derivative of atropine that is less lipid soluble and hence produces fewer central nervous system actions; a cycloplegic. Synonym: atropine methylbromide. (05 Mar 2000) |
| atropine sulfate | An anticholinergic; a widely used soluble salt of atropine. (05 Mar 2000) |
| atropine test | If an injection of atropine relieves bradycardia, the condition is due to action of the vagus; if it does not, the condition may be due to an affection of the heart itself. Synonym: atropine test. (05 Mar 2000) |