| Aschoff cell | A large cell component of rheumatic nodules in the myocardium with a characteristic nucleus and relatively little cytoplasm. (05 Mar 2000) |
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| Aschoff bodies | <pathology> Small granulomas composed of macrophages, lymphocytes and multinucleate cells grouped around eosinophilic hyaline material derived from collagen. Characteristic of the myocarditis of rheumatic fever. (18 Nov 1997) |
| Aschoff, Karl Ludwig | <person> German pathologist, 1866-1942. See: Aschoff bodies, Aschoff nodules, node of Aschoff and Tawara, Rokitansky-Aschoff sinuses, Aschoff cell. (05 Mar 2000) |
| Aschoff nodules | <pathology> Small granulomas composed of macrophages, lymphocytes and multinucleate cells grouped around eosinophilic hyaline material derived from collagen. Characteristic of the myocarditis of rheumatic fever. (18 Nov 1997) |
| rokitansky-aschoff sinuses | <radiology> Small outpouchings of gallbladder mucosa that extend through the muscularis layer, may be congenital, associated with adenomyomatosis of gallbladder (12 Dec 1998) |
| node of Aschoff and Tawara | <cardiology> The location in the heart's conduction system, between the atria and the ventricles, which conducts the normal electrical impulse from the atria to the ventricles. (27 Sep 1997) |
| carcinoma, giant cell | An epithelial neoplasm characterised by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (12 Dec 1998) |
| malignant giant cell tumour | A type of bone tumour. (12 Dec 1998) |
| giant cell | <pathology> A cell of large size, often with many nuclei. They are multinucleated masses produced by the fusion of many cells. They are often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of HIV binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus. (18 Jul 2002) |
| giant cell aortitis | <pathology> Giant cell arteritis involving the aorta. (05 Mar 2000) |
| giant cell arteritis | <pathology> An inflammatory condition of the temporal artery. It is a serious chronic vascular disease, characterised by inflammation of the walls of the blood vessels (vasculitis). The age of affected patients is usually over 50 years of age. It most often involves the carotid artery system, and can lead to blindness or stroke. It can be diagnosed by biopsy of an artery, but there is often a false negative result. Elevation of the erythrocyte sedimentation rate is typical. Treatment is with high dose steroids. Common symptoms include headaches and tenderness over the temple (temporal artery). Can be associated with polymyalgia rheumatica. See: polymyalgia rheumatica. Synonym: cranial arteritis, temporal arteritis (20 Jun 2000) |
| giant cell astrocytoma | <radiology> Malignant transformation from hamartoma (tuber) of tuberous sclerosis, enhances (unlike benign lesions), arises only about foramen of Monro, not really an astrocytoma, it's a giant-cell tumour (12 Dec 1998) |
| giant cell carcinoma | <tumour> A malignant epithelial neoplasm characterised by unusually large anaplastic cells. (05 Mar 2000) |
| giant cell carcinoma of thyroid gland | A rapidly progressive undifferentiated carcinoma observed in the thyroid gland, characterised by numerous, unusually large, anaplastic cells derived from glandular epithelium of the thyroid gland. (05 Mar 2000) |
| giant cell epulis | <dermatology, oncology> A non-neoplastic lesion characterised by a proliferation of granulation tissue containing numerous multinucleated giant cells. It occurs on the gingiva and alveolar mucosa (occasionally on other soft tissues) where it presents as a soft red-blue haemorrhagic nodular swelling. It also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis), central refers to the jaw. Microscopically similar lesions occur in the tubular bones of the hands and feet, are considered neoplastic, and may have a malignant course. Identical bony lesions may be seen in hyperparathyroidism and cherubism. See: giant cell tumour of bone. Synonym: giant cell epulis. (05 Mar 2000) |