beta-arrestin
| arrestin | A 48-kD protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches g-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals. (12 Dec 1998) |
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| arrestins | A family of inhibitory proteins that bind to tyrosine phosphorylated receptors, thereby blocking their interaction with G-proteins and effectively terminating the signalling. Arrestin (s antigen, 48 kD, from retinal rods) competes with transducin for light activated rhodopsin, thus inhibiting the response to light (adaptation). Immune responses to arrestin lead to autoimmune uveitis. Similarly, _ arrestin binds to phosphorylated _ adrenergic receptors, inhibiting their ability to activate the G protein Gs (18 Nov 1997) |
Synonyms : Retinal S Antigen, S Antigen, Retinal
Synonyms :
| arrestin |
a protein of the retina that binds activated phosphorylated rhodopsin and prevents it from binding transducin; it deactivates rhodopsin as part of the visual cycle.
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| arrestin | commanding attention |
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