| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
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| DSB | double-strand break |
| SSB | short spike burst; sicca syndrome B; single-strand break; single-stranded binding [protein]; stereos... |
| AS | Antisense |
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| S | Antisense |
| As-ODN | Antisense oligodeoxynucleotide |
| AS-ODN | Antisense oligonucleotide |
| ASO | Antisense oligonucleotide |
| antisense strand | <molecular biology> The strand of DNA which is not used during transcription to make mRNA (anticoding strand). The mRNA made during transcription thus has the same sequence as this strand, so that the eventual protein will be a sense version. (13 Jan 1998) |
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| antisense | <molecular biology> In general the complementary strand of a coding sequence of DNA (antisense DNA) or of mRNA (antisense RNA). A collection of nucleotide sequences which are not templates for synthesis but yet interact with complementary sequences in other molecules thereby causing function of those molecules to be affected. Antisense RNA hybridises with and inactivates mRNA. (12 Dec 1998) |
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| antisense DNA | <molecular biology> A synthetic DNA strand that is complementary to a particular strand of target DNA with a complementary sequence of bases. This results in preventing expression of the gene encoded. These proteins can be used to selectively turn off production of certain proteins or block viral genetic instructions, by marking them for destruction by cellular enzymes, in order to prevent the building of new virus or the infection of new cells. (14 Nov 1997) |
| antisense RNA | <molecular biology> A complementary RNA sequence that binds to (and thus blocks the transcription of) a naturally-occuring (sense) messenger RNA molecule. These proteins can be used to selectively turn off production of certain proteins or block viral genetic instructions, by marking them for destruction by cellular enzymes, in order to prevent the building of new virus or the infection of new cells. (09 Oct 1997) |
| antisense therapy | Use of antisense DNA for the inhibition of translation of a specific gene product for therapeutic purposes. (05 Mar 2000) |
| RNA, antisense | An RNA molecule which, by binding to a complementary sequence in either RNA or DNA, inhibits the function and/or completion of synthesis of the latter molecule. It is involved in various regulatory systems in vivo. Artificial antisense rnas have been used to inhibit translation of specific mRNA molecules both in living cells (eukaryotic and bacterial) and in cell-free systems. (12 Dec 1998) |
| DNA, antisense | A DNA molecule which is complementary to the sense strand (that which functions as a template for the synthesis of mRNA) but is not involved in transcription. Both strands are involved in replication. (12 Dec 1998) |
| oligonucleotides, antisense | Short fragments (usually between 2 and 12 nucleotides) of DNA or RNA that are used to hinder or block the translation or processing of mRNA. (12 Dec 1998) |
| anticoding strand | The strand of duplex DNA which is used as a template for the synthesis of mRNA. Synonym: antisense strand. (05 Mar 2000) |
| antiparallel strand | A macromolecular strand that is oriented in the opposite direction of a neighboring strand. (05 Mar 2000) |
| ATP-dependent DNA strand transferase | <enzyme> From human cell nuclei; catalyses strand exchange between homologous DNA sequences; magnesium dependent, requires ATP hydrolysis Registry number: EC 2.7.7.- Synonym: ATP-dep-DNA-str trnsfase (26 Jun 1999) |
| viral strand | See: replicative form. (05 Mar 2000) |
| minus strand | See: replicative form. (05 Mar 2000) |
| minus-strand nucleic acid | <molecular biology> An RNA or DNA strand which has the opposite sense of (would be complementary to) the mRNA of a virus. (12 Jan 1998) |
| coding strand | The strand of duplex DNA that has the same sequence as the mRNA (except that mRNA contains ribonucleotides instead of deoxyribonucleotides). Synonym: sense strand. (05 Mar 2000) |
| complementary strand | See: replicative form. (05 Mar 2000) |
| antisense strand |
the strand of a double-stranded nucleic acid that is complementary to the sense strand, in DNA being thus the template strand on which the mRNA is synthesized. Cf. sense s. See also antisense RNA.
Ãâó: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
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| antisense strand |
Most genetic material, both DNA and RNA, appears as two chains or strands of nucleotides wound together into a double helix - the common picture of DNA. Each nucleotide - A, T, C and G - has an attractive opposite (A attracts T, C attracts G). As a result, one strand, the "sense" strand, contains the information (for example, ATG-AAA) and the other strand, the "antisense" strand contains the opposite of this information (TAC-TTT - according to the pairing rules). ...
Ãâó: www.epidemic.org/glossaryText/glossaryA-B.html
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