| 영문 | alkylating agent | 한글 | 알킬화약물 |
|---|---|---|---|
| 설명 | 항암제의 일종. 이상적인 항암제는 정상적인 세포에는 해를 주지 않고 단지 암세포에만 치명적인 효과를 나타내야 한다. 이렇게 하려면 암세포만의 특이한 특성을 이해하고 그곳에만 작용하는 약물을 개발해야 한다. 현재 대부분의 항암제는 암세포가 정상 세포에 비하여 월등히 증식을 빨리한다는 특성을 이용하고 있다. 증식이 빠르다는 것은 다시 말하면 유전 정보를 가지고 있는 DNA의 복제가 빠르다는 것을 의미한다. 만약 DNA의 복제를 방해한다면 증식이 아주 빠른 암세포에게는 치명적이지만 영원히 증식을 하지 않는 DNA의 복제가 거의 필요없는)신경세포나 증식이 암세포에 비해서 아주 느린 정상세포에는 거의 영향을 주지 못한다. 하지만 신체에서도 증식이 암세포와 비슷한 수준으로 일어나는 정상적인 세포가 있는데 그것은 머리카락을 만드는 모낭세포와 소화관의 점막을 이루는 세포와 혈액의 세포를 만드는 골수 세포이다. 그러므로 항암제를 사용할 경우 암세포와 마찬가지로 이들 세포도 함께 치명적인 영향을 입을 것은 당연하다(그래서 항암제 치료시엔 머리가 빠지고 소화불량이 잘 온다). 알칼화약물의 경우에는 DNA와 직접 결합을 하여 DNA의 복제를 억제함으로써 항암제의 역할을 수행한다. |
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| 영문 | cardiotonic, cardiotonic agent | 한글 | 강심제 |
|---|---|---|---|
| 설명 | 심장의 수축력을 증감시키는 약물을 말한다. 기본적으로 심근수축력을 증강시켜 심장박출량을 증가시키는 약물이다. 강심배당체, 포스포디에스트라아제 억제제, 아드레날린 β수용체작용제, 혈관확장제 등이 있다. 대표적인 예로서는 디곡신(digoxine) 등의 디지탈리스(digitalis)가 있다. |
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| 영문 | anti-inflammatory agent | 한글 | 항염증제, 소염제, 염증약 |
|---|---|---|---|
| 설명 | 국소에 작용하여 염증을 치료하고 방지하는 약. 염증을 가라앉히는 약을 말한다. 조직을 긴축-치밀하게 하여 장액과 점액의 분비를 줄이고, 표면에 있는 작은 혈관에 빈혈을 일으켜 충혈되는 것을 방지함으로써 염증적 병변을 제거하여 모든 증세를 없앤다. 대부분의 수렴제-완화제-진양제가 이에 속한다. 중요한 성분으로는 알루미늄-비스무트-아연-납화합물(병반-페르마톨-아연화-연당 등) 등이 있다. 작용에 따라 항염증진통제와 항염증효소제로 나뉜다. |
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| DTIC | Dimethyl Triazeno Imidazole Carboxamide ; Alkylating Agent |
|---|---|
| AAT | Aachen Aphasia Test; academic aptitude test; alanine aminotransferase; alkylating agent therapy; alp... |
| SMCA | smooth muscle contracting agent; suckling mouse cataract agent |
| ALK, alk | alkaline; alkylating |
| HDV | Hepatitis D(elta) Virus = HBV associated Delta Agent |
| AA | alkylating agent |
|---|---|
| a | Agent |
| CAA | Chicken anaemia agent |
| FWA | fluorescent whitening agent |
| NMBA | Neuromuscular blocking agent |
cactus grandiflorus
| antineoplastic agent, alkylating | A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumour efficacy and the presence in their chemical structures of n-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumour cells are not completely understood. (12 Dec 1998) |
|---|
| alkylating agent | <oncology, pharmacology> A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997) |
|---|---|
| antineoplastic agent | Agents inhibiting or preventing the growth of neoplasms, checking the maturation and proliferation of malignant cells. (12 Dec 1998) |
| antineoplastic agent, combined | The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. (12 Dec 1998) |
| antineoplastic agent, hormonal | Antineoplastic agent that are used to treat hormone-sensitive tumours. Hormone-sensitive tumours may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumour regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumours may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukaemias. (12 Dec 1998) |
| antineoplastic agent, phytogenic | Agents, obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (12 Dec 1998) |
| alkylating agents | Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agent, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (12 Dec 1998) |
| antibiotics, antineoplastic | Chemical substances, produced by microorganisms, inhibiting or preventing the development of neoplasms. (12 Dec 1998) |
| antimetabolites, antineoplastic | Antimetabolites that are useful in cancer chemotherapy. (12 Dec 1998) |
| antineoplastic | Inhibiting or preventing the development of neoplasms, checking the maturation and proliferation of malignant cells. Origin: Gr. Plassein = to form (18 Nov 1997) |
| antineoplastic and immunosuppressive agents | Collective grouping for substances used to arrest the proliferation of malignant cells and those that suppress the immune response. (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |
| adrenergic blocking agent | A compound that selectively blocks or inhibits responses to sympathetic adrenergic nerve activity (sympatholytic agent) and to epinephrine, norepinephrine, and other adrenergic amines (adrenolytic agent); two distinct classes exist, alpha-and beta-adrenergic receptor blocking agent's. (05 Mar 2000) |
| adrenergic neuronal blocking agent | A drug that prevents the release of norepinephrine from sympathetic nerve terminals; it does not inhibit the responses of the adrenergic receptors to circulating epinephrine, norepinephrine, and other adrenergic amines. (05 Mar 2000) |
| agent | <pharmacology> Any power, principle or substance capable of producing an effect, whether physical, chemical or biological. Origin: L. Agens = acting (18 Nov 1997) |
| agent, antihypertensive | As the name suggests, a drug aimed at reducing high blood pressure (hypertension). (12 Dec 1998) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|