| antibody-dependent cell cytotoxicity | The phenomenon of antibody-mediated target cell destruction by non-sensitised effector cells. The identity of the target cell varies, but it must possess surface IgG whose fc portion is intact. The effector cell is a "killer" cell possessing fc receptors. It may be a lymphocyte lacking conventional b- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent. (12 Dec 1998) |
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| cytotoxicity | The quality or state of being cytotoxic. Antibody-dependent cell-mediated cytotoxicity (ADCC), a form of lymphocyte-mediated cytotoxicity that functions only if antibodies are bound to the target cell. Lymphocyte-mediated cytotoxicity, the toxic or lytic activity of T-lymphocytes, which may or may not be mediated by antibodies. Cytotoxic T lymphocytes may cause lysis of cells by production of cytolytic proteins such as perforin. B-cells may cause lysis of cells by antibody-complement binding to a target cell. Natural killer cells are cytotoxic without prior sensitization. Toxicity by lymphocytes may also be mediated by antibodies; there are three kinds of cytotoxic T-lymphocytes: those that are antigen-specific as a result of previous allergization (immunization), killer cells, and natural killer cells. See: antibody-dependent cell-mediated cytotoxicity. (05 Mar 2000) |
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| cytotoxicity, immunologic | The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitised T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. (12 Dec 1998) |
| cytotoxicity tests, immunologic | The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitised lymphocyte, an antibody, or complement. (12 Dec 1998) |
| T-cell-rich, B-cell lymphoma | <tumour> A B-cell lymphoma in which more than 90% of the cells are of T-cell origin, masking the large cells that form the neoplastic B-cell component. See: adult T-cell lymphoma. (05 Mar 2000) |
| absorption cell | A small glass chamber with parallel sides, in which absorption spectra of solutions can be obtained. (05 Mar 2000) |
| acid cell | One of the cell's of the gastric glands; it lies upon the basement membrane, covered by the chief cell's, and secretes hydrochloric acid that reaches the lumen of the gland through fine intracellular and intercellular canals (canaliculi). Synonym: acid cell, oxyntic cell. (05 Mar 2000) |
| acidophil cell | A cell whose cytoplasm or its granules stain with acid dyes. (05 Mar 2000) |
| acinar cell | Any secreting cell lining an acinus, especially applied to the cell's of the pancreas that furnish pancreatic juice and enzymes to distinguish them from the cell's of ducts and the islets of Langerhans. Synonym: acinous cell. (05 Mar 2000) |
| acinar cell tumour | A solid and cystic tumour of the pancreas, occurring in young women; tumour cells contain zymogen granules. (05 Mar 2000) |
| acinic cell adenocarcinoma | <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands. Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma. (05 Mar 2000) |
| acinic cell carcinoma | <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands. Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma. (05 Mar 2000) |
| acinous cell | Any secreting cell lining an acinus, especially applied to the cell's of the pancreas that furnish pancreatic juice and enzymes to distinguish them from the cell's of ducts and the islets of Langerhans. Synonym: acinous cell. (05 Mar 2000) |
| acoustic cell | A hair cell of the organ of Corti. (05 Mar 2000) |
| adenocarcinoma, clear cell | An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumour cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumours, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (12 Dec 1998) |
| adenoid squamous cell carcinoma | <tumour> A malignant neoplasm consisting chiefly of glandular epithelium (adenocarcinoma), usually well differentiated, with foci of metaplasia to squamous (or epidermoid) neoplastic cells. Synonym: adenoid squamous cell carcinoma. (05 Mar 2000) |