| aminoglycoside N1-acetyltransferase | <enzyme> Monoacetylates apramycin, butirosin, lividomycin and paromomycin at the c1 amino group and diacetylates ribostamycin and neomycin, at the c1 amino and possibly at the 6' amino group Registry number: EC 2.3.1.- Synonym: acc1 enzyme, paromomycin acetyltransferase (26 Jun 1999) |
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| 6'-aminoglycoside acetyltransferase-2''-aminoglycoside phosphotransferase | <enzyme> Bifunctional enzyme which confers resistance to aminoglycoside antibiotic including gentamicin, tobramycin and amikacin; type aph(2'') with two apostrophes, not quotes Registry number: EC 2.- Synonym: aac(6')-aph(2'') (26 Jun 1999) |
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| aminoglycoside | <pharmacology> A group of antibiotics active against many aerobic gram-negative and some gram-positive bacteria. They are mostly produced by fungi and contain an amino sugar, and amino-or guanido-substituted inositol ring which are attached by a glycosidic linkage to a hexose nucleus resulting in a polycationic and highly polar compound. They inhibit bacterial protein synthesis by binding to a site on the 30S ribosomal subunit thereby altering codon anticodon recognition. They are all broad-spectrum antibiotics and can cause renal toxicity and ototoxicity. Common examples are streptomycin, gentamicin, amikacin, kanamycin, tobramycin, netilmicin, neomycin, framycetin. (13 Oct 1997) |
| aminoglycoside 3'-phosphotransferase | <enzyme> A bacterial enzyme which confers resistance to the antibiotic neomycin.The APH gene is used as a selectable marker in genetic experiments, whereby bacterial cells which do not have the gene are eliminated from a population and thus selected against when exposed to neomycin. (13 Oct 1997) |
| aminoglycoside 6-adenylyltransferase | <enzyme> From bacillus subtilis marburg Registry number: EC 2.7.7.- Synonym: aminoglycoside 6-adenyltransferase, ag-6-atransferase (26 Jun 1999) |
| aminoglycoside acetyltransferase | <enzyme> See also gentamicin acetyltransferase Registry number: EC 2.3.1.- Synonym: aminocyclitol acetyltransferase, neomycin acetyltransferase (26 Jun 1999) |
| aminoglycoside N(3')-acetyltransferase | <enzyme> Catalyses the reaction of CoA and acetyl-2-deoxystreptamine antibiotic to yield acetyl-CoA and a 2-deoxystreptamine antibiotic; has broad specificity; acts on gentamicin, tobramycin, sisomicin, netilmicin, kanamycin, neomycin and apramycin Registry number: EC 2.3.1.81 Synonym: aac(3)-iv, aminoglycoside-(3)-n-acetyltransferase iv (26 Jun 1999) |
| aminoglycoside N(6')-acetyltransferase | <enzyme> The antibiotic kanamycin, gentamicin, tobramycin, and neomycin can act as an acceptor; has to be 6'-acetyltransferase Registry number: EC 2.3.1.82 Synonym: amikacin acetyltransferase, aminoglycoside-6'-n-acetyltransferase, gentamicin 6'-acetyltransferase, 6' gat gene product, aac(6') (26 Jun 1999) |
| aminoglycoside phosphoribosyltransferase | <enzyme> Coded by neo-gene; involved in kanamycin resistance; no other information given on reaction 8/93 Registry number: EC 2.4.2.- Synonym: aminoglycosidephosphoribosyltransferase (26 Jun 1999) |
| antibiotics, aminoglycoside | Antibiotics whose structure contains amino sugars attached to an aminocyclitol ring (hexose nucleus) by glycosidic bonds. Aminoglycoside antibiotics are derived from various species of streptomyces and micromonospora or are produced synthetically. They act by inhibiting protein synthesis. (12 Dec 1998) |