| tumor | 1. <oncology> An abnormal mass of tissue that results from excessive cell division that is uncontrolled and progressive, also called a neoplasm. Tumours perform no useful body function. They may be either benign (not cancerous) or malignant. 2. Swelling, one of the cardinal signs of inflammations, morbid enlargement. Origin: L. Tumere = to swell (12 May 1997) |
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| tumor marker | <investigation, oncology> A substance in the body that usually indicates the presence of cancer. These markers are usually specific to certain types of cancer and are usually found in the blood or other tissue samples. Examples are alphafetoprotein (AFP), human chorionic gonadotropin, and lactate dehydrogenase (LDH). They may be indicators of tumour stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids. (18 Jul 2002) |
| tumor necrosis factor | <cytokine> Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997) |
| alpha, alpha-phosphotrehalase | <enzyme> Forms glucose plus glucose-6-phosphate Registry number: EC 3.2.1.93 Synonym: trehalose-6-phosphate hydrolase, phospho-alpha(1,1)glucosidase, trea gene product, trec gene product (26 Jun 1999) |
| alpha,alpha-trehalose phosphorylase | <enzyme> Chemical name: alpha-d-glucopyranosyl-alpha-d-glucopyranose orthophosphate glucosyltransferase Registry number: EC 2.4.1.64 Synonym: trehalose phosphorylase (26 Jun 1999) |
| alpha-dextrin endo-1,6-alpha-glucosidase | <enzyme> An enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullalan, amylopectin, and glycogen, and in alpha-and beta-amylase limit-dextrins of amylopectin and glycogen. Compare: isoamylase. Synonym: limit dextrinase, pullulanase, R enzyme. (05 Mar 2000) |
| alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase | <enzyme> Involved in degradation of vitamin b6; forms acetic acid plus ammonia plus carbon dioxide plus alpha-hydroxymethyl-succinic monoaldehyde Registry number: EC 3.5.1.- Synonym: compound b hydrolase (26 Jun 1999) |
| cholesterol-5 alpha,6 alpha-epoxide hydrase | <enzyme> Aspect of epoxide hydrolase, EC 3.3.2.3 Pharmacological action: carcinogen Registry number: EC 3.3.2.- Synonym: cholesterol epoxide hydrase, cholesterol epoxide hydrolase (26 Jun 1999) |
| CMP-acetylneuraminate-alpha-N-acetylneuramide alpha-2,8-sialyltransferase | <enzyme> Forms ganglioside gd3 Registry number: EC 2.4.99.8 Synonym: cmp-n-acetylneuraminate-gm3 sialyltransferase, gm3-sialosyltransferase, gd3 synthase, gd3-synthase, cmp-n-acetylneuraminate-(n-acetylneuraminyl)-d-galactosyl-d-glucosylceramide sialyltransferase, sialyltransferase II, st II, g(m3) alpha-2,8-sialyltransferase, st8sia I, stii enzyme, stiii enzyme, gt3 synthase (26 Jun 1999) |
| CMP-N-acetylneuraminate-alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase | <enzyme> Enzyme from foetal calf liver; forms branched tetrasaccharide, neuac-alpha2-3gal-beta1-3(neuac-alpha2-6)galnac of fetuin Registry number: EC 2.4.99.3 Synonym: cmp-aag-sialyltransferase, st6galnaci, galnac 2,6-sialyltransferase (26 Jun 1999) |
| NAD 3 alpha-hydroxy-5 alpha-pregnan-20-one-oxidoreductase | <enzyme> From rat liver microsomes Registry number: EC 1.1.1.- Synonym: nad-3-hp-20-oor (26 Jun 1999) |
| 1,4-alpha-d-glucan 6-alpha-d-glucosyltransferase | A glucosyltransferase that transfers an alpha-glucosyl residue in a 1,4-alpha-glucan to the primary hydroxyl group of glucose in a 1,4-alpha-glucan. See: 1,4-alpha-d-glucan branching enzyme. Synonym: oligoglucan-branching glycosyltransferase. (05 Mar 2000) |
| 1,4-alpha-glucan 6-alpha-glucosyltransferase | <enzyme> From aspergillus niger and oryzae Registry number: EC 2.4.1.24 (26 Jun 1999) |
| 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid | <chemical> A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of vasopressin and activation of phospholipase c. Pharmacological action: vasoconstrictor agents. Chemical name: 5-Heptenoic Acid, 7-(6-(3-Hydroxy-1-Ocentyl)-2-Oxabicyclo(2.2.1)hept-5-yl)-, (1R-(1alpha,4alpha,5 beta(Z),6alpha(1E,3S*)))- (12 Dec 1998) |
| 5 alpha-3 alpha-hydroxysteroid dehydrogenase | <enzyme> Androsterone can be substrate Registry number: EC 1.1.1.50 Synonym: 3 alpha-hydroxysteroid dehydrogenase, 3 alpha-hydroxysteroid oxidoreductase, 3 oc-hydroxysteroid dehydrogenase (26 Jun 1999) |