| allogeneic bone marrow transplant | <haematology, procedure> A bone marrow transplant using marrow collected from a matched healthy donor, usually a brother or sister. The risks associated with the transplant increase with age and 50 years of age is generally regarded as the upper limit. (13 Nov 1997) |
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| bone marrow transplantation | <oncology, procedure> Treatment in which healthy bone marrow replaces bone marrow that has been affected by a disease or by treatment for a disease. Acronym: BMT (12 May 1997) |
| allogeneic | <genetics, immunology> Two or more individuals (or strains) are stated to be allogeneic to one another when the genes at one or more loci are not identical in sequence in each organism. Allogenicity is usually specified with reference to the locus or loci involved. (18 Nov 1997) |
| allogeneic antigen | Genetic variations of the same antigens within a given species. (05 Mar 2000) |
| allogeneic graft | <haematology> Grafts between two or more individuals allogeneic at one or more loci (usually with reference to histocompatibility loci). As opposed to autograft and xenograft. (18 Nov 1997) |
| allogeneic inhibition | Inhibition or injury to allogeneic cells that occurs when lymphocytes are mixed and cultured with other cells of different genotypes in vitro. (05 Mar 2000) |
| allogeneic transplant | <haematology, procedure> A transplant of an organ or tissue that is donated either by agenetically matched relative of the patient or by an unrelated (but genetically similar) donor. (09 Oct 1997) |
| autologous bone marrow transplant | <haematology, procedure> A process in which a patients healthy bone marrow is withdrawn and preserved. It is later injected back into the patient to replace bone marrow damaged by high doses of radiation therapy. It can then produce healthy blood cells. This treatment is used to offset the detrimental effects of high-dose radiation used in certain types of cancer. (31 Dec 1997) |
| bone marrow | <haematology> The soft, spongy tissue found in the centre of most large bones that produces the cellular components of blood: white cells, red cells and platelets (haemopoiesis). It is also the most radiation sensitive tissue of the body. (12 May 1997) |
| bone marrow aspirate | <procedure> A small volume of bone marrow removed under local or general anaesthetic from either the hip bone (pelvis) or breast bone (sternum). The cells in the sample can then be examined under the microscope to identify any abnormality in the developing blood cells. (13 Nov 1997) |
| bone marrow aspiration | <procedure> Procedure used to remove a sample of bone marrow, usually from the rear hip bone, for examination under the microscope. (16 Dec 1997) |
| bone marrow biopsy | <procedure> A test involving the insertion of a thin needle into the breastbone or more commonly, the hip, in order to aspirate a sample of the marrow. A small piece of cortical bone may also be obtained for biopsy. Anaemia of unknown cause is often investigated using this test. (27 Sep 1997) |
| bone marrow biopsy and aspiration | <procedure> A procedure in which a needle is inserted into the centre of a bone, usually the hip, to remove a small amount of bone marrow for microscopic examination. (09 Oct 1997) |
| bone marrow cells | The fat cells (adipocytes), large nucleated cells or myelocytes, and giant cells called megakaryocytes, filling the meshes making up the bone marrow, a meshwork of connective tissue containing branching fibres. (12 Dec 1998) |
| bone marrow dose | The cumulative dose to the blood-forming organ from therapeutic or nuclear fallout irradiation; the presumed leukemogenic dose. (05 Mar 2000) |