| 영문 | alkylating agent | 한글 | 알킬화약물 |
|---|---|---|---|
| 설명 | 항암제의 일종. 이상적인 항암제는 정상적인 세포에는 해를 주지 않고 단지 암세포에만 치명적인 효과를 나타내야 한다. 이렇게 하려면 암세포만의 특이한 특성을 이해하고 그곳에만 작용하는 약물을 개발해야 한다. 현재 대부분의 항암제는 암세포가 정상 세포에 비하여 월등히 증식을 빨리한다는 특성을 이용하고 있다. 증식이 빠르다는 것은 다시 말하면 유전 정보를 가지고 있는 DNA의 복제가 빠르다는 것을 의미한다. 만약 DNA의 복제를 방해한다면 증식이 아주 빠른 암세포에게는 치명적이지만 영원히 증식을 하지 않는 DNA의 복제가 거의 필요없는)신경세포나 증식이 암세포에 비해서 아주 느린 정상세포에는 거의 영향을 주지 못한다. 하지만 신체에서도 증식이 암세포와 비슷한 수준으로 일어나는 정상적인 세포가 있는데 그것은 머리카락을 만드는 모낭세포와 소화관의 점막을 이루는 세포와 혈액의 세포를 만드는 골수 세포이다. 그러므로 항암제를 사용할 경우 암세포와 마찬가지로 이들 세포도 함께 치명적인 영향을 입을 것은 당연하다(그래서 항암제 치료시엔 머리가 빠지고 소화불량이 잘 온다). 알칼화약물의 경우에는 DNA와 직접 결합을 하여 DNA의 복제를 억제함으로써 항암제의 역할을 수행한다. |
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| DTIC | Dimethyl Triazeno Imidazole Carboxamide ; Alkylating Agent |
|---|---|
| AAT | Aachen Aphasia Test; academic aptitude test; alanine aminotransferase; alkylating agent therapy; alp... |
| ALK, alk | alkaline; alkylating |
| OHA | Oral Hypoglycemic Agents |
| CTA | Canadian Tuberculosis Association; chemotactic activity; chromotropic acid; Committee on Thrombolyti... |
| AA | alkylating agent |
|---|---|
| CWA | Chemical warfare agents |
| DBA | Dentin bonding agents |
| NSAID | non steroidal anti-inflammatory agents |
| NSAIA | Non-steroidal anti-inflammatory agents |
| alkylating agents | Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agent, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (12 Dec 1998) |
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| alkylating agent | <oncology, pharmacology> A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997) |
|---|---|
| antineoplastic agent, alkylating | A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumour efficacy and the presence in their chemical structures of n-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumour cells are not completely understood. (12 Dec 1998) |
| abortifacient agents | Chemical substances that interrupt pregnancy after implantation. (12 Dec 1998) |
| abortifacient agents, non-steroidal | Non-steroidal chemical compounds with abortifacient activity. (12 Dec 1998) |
| abortifacient agents, steroidal | Steroidal compounds with abortifacient activity. (12 Dec 1998) |
| adrenergic agents | Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (12 Dec 1998) |
| anti-allergic agents | Agents that are used to treat allergic reactions. most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (12 Dec 1998) |
| anti-allergic and respiratory system agents | A collective term for drugs used to treat allergic reactions as well as those drugs that produce an effect on the respiratory system. (12 Dec 1998) |
| anti-anxiety agents | Agents that alleviate anxiety, tension, and neurotic symptoms, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. Some are also effective as anticonvulsants, muscle relaxants, or anaesthesia adjuvants. Adrenergic beta-antagonists are commonly used in the symptomatic treatment of anxiety but are not included here. Substances with a benzodiazepine ring structure widely used to treat anxiety and neuroses. Drugs in this class also generally have sedative or weak hypnotic properties and may be effective as muscle relaxants, anticonvulsants, and anaesthesia adjuvants. (12 Dec 1998) |
| anti-arrhythmia agents | Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (12 Dec 1998) |
| anti-asthmatic agents | Drugs that are used to treat asthma. (12 Dec 1998) |
| anticarcinogenic agents | Agents that reduce the frequency or rate of spontaneous or induced tumours independently of the mechanism involved. They differ from antineoplastic agent in that they prevent neoplasms from forming. The anticarcinogenic substances can be divided into three categories. The first consists of compounds that prevent the formation of carcinogens from precursor substances. The second group consists of "blocking agents" which inhibit carcinogenesis by preventing carcinogenic agents from reaching or reacting with critical target sites in the tissues. The third group is the "suppressor agents" which act by suppression of expression of neoplasia in cells previously exposed to carcinogens that would otherwise cause neoplasms. (12 Dec 1998) |
| anticestodal agents | Agents used to treat tapeworm infestations in man or animals. (12 Dec 1998) |
| anticholesteraemic agents | Substances that promote a reduction of blood cholesterol levels. (12 Dec 1998) |
| anti-coagulant agents | Medications, like heparin, used as blood-thinners to prevent blood clots and to maintain open blood vesssels. (12 Dec 1998) |
Synonyms : Alkylators, Agents, Alkylating
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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