| alkyl | 1. A hydrocarbon radical of the general formula CnH2n+1. 2. A compound, such as tetraethyl lead, in which a metal is combined with alkyl radicals. Synonym: alkide. (05 Mar 2000) |
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| alkyl and aryl transferases | <enzyme> A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). Registry number: EC 2.5 (12 Dec 1998) |
| alkyl dihydroxyacetone phosphate oxidoreductase | <enzyme> Forms alkyl-sn-glycerol 3-phosphate, uses NADPH Registry number: EC 1.1.1.- (26 Jun 1999) |
| alkyl group | <chemistry> A funtional group on an organic molecule which is derived from an alkane which has lost a hydrogen atom. (13 Nov 1997) |
| alkyl hydroperoxide reductase | <enzyme> Reduces an alkyl hydroperoxide to the corresponding alcohol in the presence of NADPH; ahpc gene product from salmonella typhimurium Registry number: EC 1.- Synonym: ahpc gene product, alkylhydroperoxide reductase, ahpf gene product (26 Jun 1999) |
| alkylacetylglycerophosphatase | <enzyme> Involved in the synthesis of platelet-activating factor Registry number: EC 3.1.3.59 Synonym: alkylacetyl-gp phosphohydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase (26 Jun 1999) |
| alkylamine | An alkane containing an -NH2 group in place of one H atom; e.g., ethylamine. (05 Mar 2000) |
| alkylating agent | <oncology, pharmacology> A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997) |
| alkylating agents | Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agent, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (12 Dec 1998) |
| alkylation | The substitution of an alkyl group for an active hydrogen atom in an organic compound. (12 Dec 1998) |
| alkyldihydroxyacetone phosphate acyltransferase | <enzyme> Catalyses acylation of alkyl-dhap Registry number: EC 2.3.1.- Synonym: adapat (26 Jun 1999) |
| alkylglycerol kinase | <enzyme> Forms 1-alkyl-2-lyso-sn-glycero-3-phosphate Registry number: EC 2.7.1.93 Synonym: alkylglycerol phosphotransferase (26 Jun 1999) |
| alkylglycerone-phosphate synthase | <enzyme> Replaces the acyl moiety of acyldhap with a long chain fatty alcohol; intact alcohol including the oxygen atom is incorporated into alkyl-dhap Registry number: EC 2.5.1.26 Synonym: adhps, alkyl-dihydroxyacetone phosphate synthase, alkyl-dhap synthase, alkyldihydroxyacetone phosphate synthetase, acylglycerone-3-phosphate-long chain-alcohol o-3-phospho-2-oxopropanyl transferase, alkyldihydroxyacetonephosphate synthase (26 Jun 1999) |
| alkylglycerophosphoethanolamine phosphodiesterase | <enzyme> From microsomal preparations of rabbit kidney medulla; hydrolyzes choline moiety from lyso-paf to form 1-alkyl-2-lysoglycerophosphate in rat brain and other tissue; only lysoglycerophospholipids with ether linkages at the sn-1 position serve as substrates; acyl analogs are not utilised; requires magnesium Registry number: EC 3.1.4.39 Synonym: lysophospholipase d (26 Jun 1999) |
| alkylhalidase | <enzyme> Acts on haloalkanes to form aldehyde and halogen(s) Registry number: EC 3.8.1.1 Synonym: haloalkane dehalogenase, 1-chlorohexane halidohydrolase, lina-like gene product, dhaa gene product (26 Jun 1999) |
| acetyl-CoA-1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase | <enzyme> Transfers acetate from acetyl CoA to the sn-2-position of 1-alkyl-2-lyso-glycerophosphocholine, forming the substrate for 1-alkylglycerophosphocholine acetyltransferase (EC 2.3.1.67) Registry number: EC 2.3.1.- Synonym: acopc acetyltransferase, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine-acetyl CoA acetyltransferase, alkyllyso-gp-acetyl-CoA acetyltransferase, acetyl-coenzyme a-1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase (26 Jun 1999) |
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| acyl-CoA-1-O-alkyl-2-acetyl-sn-glycerol acyltransferase | <enzyme> From hl-60 cells; related to platelet-activating factor metabolism Registry number: EC 2.3.1.- Synonym: acyl-CoA-1-o-hexadecyl-2-acetyl-sn-glycerol acyltransferase, acaag-acyltransferase, acyl-coenzyme a-1-o-alkyl-2-acetyl-sn-glycerol acyltransferase (26 Jun 1999) |
| 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase | <enzyme> Alkylacylglycerophosphorylethanolamine alk-1-enylacyl-glycerophosphorylethanolamine (ethanolamine plasmalogen) type of reaction (cis-olefination), cofactor requirement resembles fatty acid desaturases Registry number: EC 1.14.99.- (26 Jun 1999) |