| adenosine nucleosidase | <enzyme> An enzyme hydrolyzing adenosine to adenine and d-ribose. Synonym: adenosinase. (05 Mar 2000) |
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| pyrimidine-5'-nucleotide nucleosidase | <enzyme> Also acts on some deoxyribonucleotides Registry number: EC 3.2.2.10 Synonym: pyr-5'-nt-nucleosidase (26 Jun 1999) |
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| NAD+ nucleosidase | <enzyme> An enzyme that catalyses the hydrolysis of NAD to nicotinamide and adpribose. Chemical name: NAD+ glycohydrolase Registry number: EC 3.2.2.5 (12 Dec 1998) |
| NAD(P)+ nucleosidase | <enzyme> An enzyme hydrolyzing NAD(P)+ to release free nicotinamide and adenosinediphosphoribose(phosphate). (05 Mar 2000) |
| nucleosidase | <enzyme> Catalyses hydrolysis of n-ribosyl-purine into a purine and d-ribose Registry number: EC 3.2.2.1 Synonym: purine nucleoside hydrolase, guanosine hydrolase (26 Jun 1999) |
| uridine nucleosidase | <chemical> Chemical name: nucleosidase, uridine Synonym: uridine ribohydrolase (26 Jun 1999) |
| adenosine | <biochemistry> A ribonucleotide which consists of the nitrogenous base adenine linked to the sugar ribose. <drug> A cardiac drug used in terminating PSVT involving reentry pathways that include the AV node or Wolff-Parkinson-White syndrome. For atrial flutter, atrial fibrillation, atrial or ventricular tachycardias, adenosine may produce transient AV block that may help identify the rhythm. Pharmacologic action: Endogenous purine nucleoside that depresses AV node and sinus node activity. Brief duration of action (1-2 min). Dose: Rapid 6 mg IV bolus over 1-3 sec. May repeat at 12 mg IV bolus within 1-2 min Patients taking theophylline may require larger doses. Use a smaller dose with cardiac transplant patients. Potential complications: Common but transient - flushing, dyspnea, chest pain, bradycardia, and ventricular ectopy. Theophylline (and caffeine) blocks adenosine's effects. Dipyridamole potentiates adenosine's effects. Use other agents to avoid these drug interactions. (15 Mar 2000) |
| adenosine 3',5'-cyclic monophosphate | An activator of phosphorylase kinase and an effector of other enzymes, formed in muscle from ATP by adenylate cyclase and broken down to 5'-AMP by a phosphodiesterase; sometimes referred to as the "second messenger." A related compound (2',3') is also known. Synonym: cyclic adenylic acid, cyclic AMP, cyclic phosphate. Acronym: cAMP (05 Mar 2000) |
| adenosine 3',5'-cyclic phosphate phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of adenosine 3',5'-cyclic phosphate forming 5'-AMP. A crucial step in the regulation of cellular adenosine 3',5'-cyclic phosphate levels. Inhibited by caffeine. Synonym: cAMP phosphodiesterase. (05 Mar 2000) |
| adenosine 3'-phosphate | 3'-Adenylic acid. See: adenylic acid. (05 Mar 2000) |
| adenosine 3'-phosphate 5'-phosphosulfate | 3'-phosphoadenosine 5'-phosphosulfate;an intermediate in the formation of urinary ethereal sulfates, notable for containing a "high energy" sulfate bond; the 3'-OH of adenosine is replaced by -OPO3H2, the 5'-OH by -OP(O2H)-OSO3H. Synonym: active sulfate. Acronym: PAPS (05 Mar 2000) |
| adenosine 5'-diphosphate | A condensation product of adenosine with pyrophosphoric acid, formed from ATP by the hydrolysis of the terminal phosphate group of the latter compound. Acronym: ADP (05 Mar 2000) |
| adenosine-5'-(n-ethylcarboxamide) | <chemical> A stable adenosine a1 and a2 receptor agonist. Experimentally, it inhibits camp and cgmp phosphodiesterase activity. Pharmacological action: antineoplastic agent, vasodilator agents. (12 Dec 1998) |
| adenosine 5'-phosphate | 5'-Adenylic acid. See: adenylic acid. (05 Mar 2000) |
| adenosine 5'-phosphoramidate hydrolase | <enzyme> Hydrolyzes nucleoside 5'-monophosphoramidates into nucleoside 5'-phosphates and ammonia Registry number: EC 3.9.1.- Synonym: ampn hydrolase, nucleoside monophosphoramidate hydrolase (26 Jun 1999) |
| adenosine 5'-phosphosulfate | An intermediate in the formation of PAPS (active sulfate). Adenosine 5'-phosphosulfate kinase, the enzyme that catalyses the formation of active sulfate from adenosine 5'-phosphosulfate and ATP. Acronym: APS (05 Mar 2000) |