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acyl-CoA dehydrogenase [EC 1.3.99.3] any of several enzymes of the oxidoreductase class that catalyze the oxidation of acyl coenzyme A thioesters to the enoyl coenzyme A form, using a flavin electron acceptor. The reaction is a step in the degradation of fatty acids and the trans isomer of enoyl coenzyme A is formed exclusively. Individual enzymes are specific for certain ranges of acyl chain lengths. See also electron transfer flavoprotein, under flavoprotein.
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