| activated acetaldehyde | The activated form of acetaldehyde that is formed during the decarboxylation of active pyruvate. Formed in alcohol fermentation and in carbohydrate metabolism. Synonym: a-hydroxyethylthiamin pyrophosphate. (05 Mar 2000) |
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| activated amino acid | The product formed by the condensation of the acyl radical of an amino acid and adenosine 5'-monophosphate (originally in the form of adenosine 5'-triphosphate, with elimination of a pyrophosphoric group). Formed in the first step of protein biosynthesis. Synonym: activated amino acid. (05 Mar 2000) |
| activated atom | An atom possessing more than normal energy as a result of input of energy. See: excited state. Synonym: excited atom. (05 Mar 2000) |
| activated carboxylic acid | Derivative of a carboxyl group that is more susceptible to nucleophilic attack than a free carboxyl group; e.g., acid anhydrides, thioesters. (05 Mar 2000) |
| activated charcoal | <drug> A type of carbon produced through exposing a source material such as wood or bone to very high temperatures in the presence of steam, air or carbon monoxide. Activated carbon is very good at removing (adsorbing) contaminants and is used in water filters, to decolour solutions and is sometimes administered to poisoning victims. (15 Jan 1998) |
| activated choline | An intermediate in the formation of phosphatidylcholine (lecithin); formed by the action of cytidine 5'-triphosphate on phosphocholine, linking the choline phosphate group to the alpha-phosphate of the cytidine 5'-triphosphate to give a pyrophosphate. Synonym: activated choline, cytidine diphosphate choline. (05 Mar 2000) |
| activated clotting time | The most common test used for coagulation time in cardiovascular surgery. (05 Mar 2000) |
| activated complex | <chemistry> State of highest energy during a reaction. When reactants form the activated complex, bond breaking and bond formation is occurring. Synonym: transition state. (09 Jan 1998) |
| activated fatty acid | A fatty acyl-coenzyme A thiol ester. (05 Mar 2000) |
| activated glucose | A nucleoside diphosphoglucose such as UDP glucose. (05 Mar 2000) |
| activated macrophage | A mature macrophage, in an active metabolic state, that is cytotoxic to tumour/target cells, usually following exposure to certain cytokines. Synonym: armed macrophage. (05 Mar 2000) |
| activated partial thromboplastin time | The time needed for plasma to form a fibrin clot following the addition of calcium and a phospholipid reagent; used to evaluate the intrinsic clotting system. (05 Mar 2000) |
| activated resin | Autopolymerizing resin, any resin that can be polymerised by chemical catalysis rather than by the application of heat; used in dentistry for dental restoration, denture repair, and impression trays. Synonym: activated resin, cold cure resin, cold-curing resin, quick cure resin, self-curing resin. (05 Mar 2000) |
| activated sludge | See: activated sludge method. (05 Mar 2000) |
| activated sludge method | A method of sewage disposal in which the sewage is treated with 15% bacterially active, liquid sludge, which is produced by repeated vigorous aeration of fresh sewage to form floccules or sediment; when this flocculation process is complete, the resulting activated sludge contains large numbers of bacteria, together with yeasts, molds, and protozoa, which actively effect the oxidation of organic compounds; this mixture is piped to a sedimentation tank, the effluent from which is completely treated sewage. (05 Mar 2000) |
| AMP-activated protein kinase kinase | <enzyme> An endogenous kinase kinase; reactivates the inactive form of AMP-activated protein kinase (AMP-pk); phosphorylates the 63-kD subunit of AMP-pk Registry number: EC 2.7.1.- Synonym: AMP-pk reactivator, hmg CoA reductase kinase kinase (26 Jun 1999) |
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| basic polypeptide-activated protein kinase | <enzyme> Requires mn2+ for its activity; from bombyx mori; does not require cyclicamp, cyclicgmp or ca Registry number: EC 2.7.1.- Synonym: ba kinase (26 Jun 1999) |
| calcium-calmodulin-activated histone 3 arginine kinase | <enzyme> From nuclear extracts of dividing and quiescent rat heart endothelial cells; represents a new class of ca-cam-dependent kinases which phosphorylate arg Registry number: EC 2.7.10.- Synonym: ca(2+)-calmodulin-activated histone 3 arg kinase, ca-cam h3 kinase (26 Jun 1999) |
| Receptors for activated C Kinase | Synonym for endosome. (18 Nov 1997) |
| caspase-activated deoxyribonuclease | <enzyme> Degrades DNA during apoptosis, inhibited by icad (inhibitor of cad); a protein of 343 amino acids carrying a nuclear localization signal. Registry number: EC 3.1.- Synonym: cad enzyme, caspase-activated dnase (26 Jun 1999) |
| ceramide-activated protein kinase | <enzyme> Mw 97 kD; stimulation of kinase takes place during sphingomyelin pathway; has membrane-bound activity capable of phosphorylating a peptide derived from the sequence surrounding thr(699) of the epidermal growth factor receptor; has role in signal transduction for tumour necrosis factor Registry number: EC 2.7.10.- Synonym: cap kinase (26 Jun 1999) |
| ceramide-activated protein phosphatase | <enzyme> Belongs to the heterotrimeric subfamily of the pp2a group of serine-threonine protein phosphatases; involved in ceramide-mediated signal transduction; inhibited by okadaic acid Registry number: EC 3.1.3.- Synonym: ceramide-stimulated phosphatase, capp (enzyme) (26 Jun 1999) |
| monocytes, activated killer | Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. Akm cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |
| platelet endothelial cell activated protease | <enzyme> Degrades casein and fibrinogen; secreted by endothelial cells and activated in the extracellular medium by platelets; not inhibited by serine protease inhibitors, metalloproteinase inhibitors, or cystein protease inhibitors; pH optimum 7.5 Registry number: EC 3.4.99.- Synonym: pecap (26 Jun 1999) |
| DNA-activated protein kinase | <enzyme> Nuclear serine-threonine protein kinase that phosphorylates DNA-binding proteins; may function in cell homeostasis Registry number: EC 2.7.10.- Synonym: DNA-pk, DNA-dependent protein serine-threonine kinase, DNA-dependent protein kinase, scid gene product, xrcc7 gene product (26 Jun 1999) |
| immunologically activated cell | An immunocyte that is in an elevated state of reactivity capable of carrying out an immune response, in contradistinction to an immunologically competent cell. (05 Mar 2000) |
| thiol activated haemolysins | Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function. Oxidation (to disulphide bridges) inactivates the toxin. Examples: tetanolysin, streptolysin O, _ toxin, cereolysin. (18 Nov 1997) |
| TNF-IL1-activated protein kinase | <enzyme> Phosphorylates beta casein in vitro; not the same as casein kinase 1 and casein kinase 2; not activated by mitogens, celllular stresses or any other cytokines than il1 and tnf Registry number: EC 2.7.1.- Synonym: tip kinase, beta casein kinase (26 Jun 1999) |
| Fas-activated serine-threonine kinase | <enzyme> Phosphorylates tia-1 during fas-mediated apoptosis; contains proline-rich sh3-binding domains; mw 60-63 kD; genbank x86779 Registry number: EC 2.7.10.- Synonym: fast kinase (26 Jun 1999) |
| killer cells, lymphokine-activated | Cytolytic lymphocytes with the unique capacity of killing natural killer (nk)-resistant fresh tumour cells. They are interleukin-2-activated nk cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. Lak cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |