| acetoacetyl-CoA | Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA; major role is condensation with acetyl-CoA to form the important beta-hydroxy-beta-methylglutaryl-CoA. Synonym: acetoacetyl-coenzyme A. (05 Mar 2000) |
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| acetoacetyl-CoA reductase | An oxidoreductase catalyzing interconversion of a 3-oxoacyl-CoA and NADPH, and the corresponding d-3-hydroxyacyl-CoA, and NADP+. A step in fatty acid synthesis. (05 Mar 2000) |
| acetoacetyl-CoA synthetase | <enzyme> Catalyses the conversion of acetoacetate and CoA in the presence of ATP to yield AMP, pyrophosphate and acetoacetyl-CoA; the latter is the first intermediate in cholesterogenesis; also acts more slowly on l-3-hydroxybutanoate Registry number: EC 6.2.1.16 Synonym: acetoacetyl-CoA ligase, acetoacetate-CoA ligase, acetoacetyl-coenzyme a synthetase (26 Jun 1999) |
| acetoacetyl-CoA thiolase | An acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis. Synonym: acetoacetyl-CoA thiolase, acetyl-CoA thiolase, thiolase. (05 Mar 2000) |