| acetoacetyl-CoA | Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA; major role is condensation with acetyl-CoA to form the important beta-hydroxy-beta-methylglutaryl-CoA. Synonym: acetoacetyl-coenzyme A. (05 Mar 2000) |
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| acetoacetyl-CoA reductase | An oxidoreductase catalyzing interconversion of a 3-oxoacyl-CoA and NADPH, and the corresponding d-3-hydroxyacyl-CoA, and NADP+. A step in fatty acid synthesis. (05 Mar 2000) |
| acetoacetyl-CoA synthetase | <enzyme> Catalyses the conversion of acetoacetate and CoA in the presence of ATP to yield AMP, pyrophosphate and acetoacetyl-CoA; the latter is the first intermediate in cholesterogenesis; also acts more slowly on l-3-hydroxybutanoate Registry number: EC 6.2.1.16 Synonym: acetoacetyl-CoA ligase, acetoacetate-CoA ligase, acetoacetyl-coenzyme a synthetase (26 Jun 1999) |
| acetoacetyl-CoA thiolase | An acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis. Synonym: acetoacetyl-CoA thiolase, acetyl-CoA thiolase, thiolase. (05 Mar 2000) |
| acetoacetyl-acyl carrier protein synthase | <enzyme> E coli enzyme, that catalyses condensation of malonyl-acyl carrier protein plus acetyl-acyl carrier protein; not inhibited by cerulenin Registry number: EC 2.3.1.- Synonym: acetoacetyl-acp synthase (26 Jun 1999) |
| acetoacetyl-coenzyme A | Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA; major role is condensation with acetyl-CoA to form the important beta-hydroxy-beta-methylglutaryl-CoA. Synonym: acetoacetyl-coenzyme A. (05 Mar 2000) |
| acetoacetyl-succinic thiophorase | <enzyme> An enzyme catalyzing the reversible conversion of acetoacetyl-CoA and succinate into succinyl-CoA and acetoacetate; malonyl-CoA can substitute for succinyl-CoA and a few other 3-oxo acids for the acetoacetate; an important step in order for the ketone bodies to serve as a fuel for extrahepatic tissues. Synonym: 3-ketoacid-CoA transferase, acetoacetyl-succinic thiophorase. (05 Mar 2000) |
| butyryl-CoA acetoacetate CoA transferase | <enzyme> Butyryl-CoA + acetoacetate yields butyrate + acetoacetyl-CoA Registry number: EC 2.8.3.- Synonym: butyryl-coenzyme a acetoacetate coenzyme a transferase (26 Jun 1999) |
| malonyl-CoA-acetyl CoA-acyl carrier protein S-acyltransferase | <enzyme> Specific for either malonyl-CoA or acetyl-CoA; a component of fatty acid synthase Registry number: EC 2.8.3.- Synonym: mcoa-acoa acp acyltransferase (26 Jun 1999) |
| succinyl-CoA-3-hydroxy-3-methylglutarate CoA transferase | <enzyme> Rat liver mitochondrial enzyme which catalyses transfer of a conezyme a molecule from succinyl-CoA to 3-hydroxy-3-methylglutarate Registry number: EC 2.8.3.- Synonym: succinylcoa-hmg CoA transferase, sca-hmg cat (26 Jun 1999) |
| succinyl CoA propionate CoA-transferase | <enzyme> Succinyl CoA and propionate gives propionyl CoA and succinate Registry number: EC 2.8.3.- Synonym: succinyl coenzyme a propionate coenzyme a-transferase (26 Jun 1999) |
| enoyl-CoA hydratase - 3-hydroxyacyl-CoA dehydrogenase - dodecanoyl-coenzyme A delta-isomerase | <chemical> Catalyses the second and third reactions of the fatty acid beta-oxidation cycle, converting enoyl-CoA to 3-ketoacyl-CoA; EC 4.2.1.17 and EC 1.1.1.35 and EC 5.3.3.8; consider also multifunctional protein-a Synonym: peroxisomal bifunctional enzyme, enoyl-coenzyme a hydratase -- 3-hydroxyacyl-coenzyme a dehydrogenase, peroxisomal trifunctional enzyme, delta(3), delta(2)-enoyl-CoA isomerase--2-enoyl-CoA hydratase--3-hydroxyacyl-CoA dehydrogenase (26 Jun 1999) |
| acetate-CoA ligase | <enzyme> An enzyme that catalyses the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. Chemical name: Acetate:CoA ligase (AMP-forming) Registry number: EC 6.2.1.1 (12 Dec 1998) |
| acetate-succinate CoA-transferase | <enzyme> Tritichomonas and trichomonas enzyme converts acetyl-CoA and succinate to acetate and succinyl-CoA Registry number: EC 2.8.3.- Synonym: acetate-succinate coenzyme a-transferase (26 Jun 1999) |
| acetyl-CoA | <enzyme> Condensation product of coenzyme A and acetic acid, symbolised as CoAS~COCH3; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis. This coenzyme plays a huge role in intermediary metabolism, in which cells synthesise, break down or use nutrient molecules for energy production, growth, etc. Acetyl-coenzyme A synthase is found in bacteria and plants and catalyses the reaction in which acetate enters metabolic pathways and forms acetyl-coenzyme A. Synonym: acetyl-coenzyme A, active acetate. (05 Mar 2000) |