| a fetoprotein | A protein normally produced during the 12th to 15th week of gestation, decreasing thereafter, but appearing in the blood in certain tumours, such as embryonal carcinomas of the testis and ovary, hepatoma, and less often in patients with carcinomas of the pancreas, stomach, colon, or lung. When present, a useful marker in following the course of a tumour. (05 Mar 2000) |
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| alpha-fetoprotein | <protein, tumour marker> A protein substance that is normally produced by the liver cells. It is one of the first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states. Measurement of the alpha-fetoprotein level in the bloodstream has been used as a early detection test for some forms of cancer (hepatocellular carcinoma). Alpha-fetoprotein can also be an important marker in the fluid obtained by amniocentesis for the prenatal diagnosis of anencephaly and other open neural tube defects such as spina bifida. Elevated in: wrong dates for a pregnancy, multiple gestation, midline closure (neural-tube) defects, encephalocele, anencephaly, liver tumours, hepatoblastoma, haemangioendothelioma (occasionally, mild), hepatocellular carcinoma (HCC, hepatoma). The level produced by liver tumours (hepatomas), germ cell tumours (teratocarcinoma and embryonal cell carcinomas) permits the monitoring of response to treatment of these tumours. Decreased in: wrong dates for a pregnancy, chromosome abnormality (including Down syndrome) Acronym: AFP (27 Jun 1999) |
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| maternal serum alpha-fetoprotein | A plasma protein, alpha-fetoprotein (afp) is normally produced by the foetus. The level of afp in the blood serum of pregnant women provides a screening test for open neural tube defects (anencephaly and spina bifida) and for down syndrome (and other chromosome abnormalities). The maternal serum afp (msafp) tends to be unusally high with open neural tube defects and unsually low with down syndrome. (12 Dec 1998) |