| zalcitabine |
Zalcitabine (2'-3'-dideoxycytidine, ddC), is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3' with a hydrogen. It is phosphorylated in the T cell into its active triphosphate form, ddCTP. This active metabolite works as a substrate for the reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. ...
출처: en.wikipedia.org/wiki/Zalcitabine
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| zalcitabine |
a nucleoside analog drug that inhibits HIV replication by interfering with the reverse transcriptase enzyme. The drug is FDA-approved for the treatment of HIV disease; current practice favors use in combinations. Adverse side effects may include nausea, peripheral neuropathy, oral ulcers and pancreatitis.
출처: cas.umkc.edu/psyc/motiv8/glossary.htm
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