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X-His dipeptidase [EC 3.4.13.3] an enzyme of the hydrolase class that catalyzes the cleavage of the dipeptide carnosine into component amino acids β-alanine and histidine; it also acts on some other aminoacyl-L-histidine dipeptides. The tissue isozyme requires zinc ions and does not hydrolyze anserine or homocarnosine; the serum isozyme requires cadmium and does hydrolyze anserine and homocarnosine. Deficiency of the serum isozyme causes serum carnosinase deficiency. Called also carnosinase and aminoacyl-histidine dipeptidase. See also homocarnosinase.
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