| Von Willebrand factor | Plasma factor involved in platelet adhesion through an interaction with Factor VIII. See: Von Willebrand disease. (18 Nov 1997) |
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| von Willebrand factor-degrading protease | <enzyme> A large protease from normal human plasma that degrades vwf at the 842tyr-843met peptide bond Registry number: EC 3.4.24.- Synonym: vwf-cleaving protease (26 Jun 1999) |
| Von Willebrand disease | <disease, haematology> A hereditary platelet disorder caused by defective or deficient Von Willebrand factor, a protein involved in normal blood clotting, that reduces adhesion to collagen but not aggregation. Both bleeding time and coagulation are increased. Factor VIII levels are secondarily reduced. Symptoms include nosebleeds, bleeding gums, heavy menstrual bleeding, bruising and skin rashes. Inheritance: autosomal dominant. (30 Sep 1997) |
| von Willebrand, E | <person> Finnish physician, 1870-1949. See: von Willebrand's disease. (05 Mar 2000) |
| Von Willebrand's disease | <disease> This congenital disease, which is caused a deficiency of a blood factor that promotes platelet adhesion, is characterised by prolonged bleeding and poor blood coagulation. (09 Oct 1997) |
| accelerator factor | <chemical> Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor v accomplishes this by forming a complex with factor xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor v leads to owren's disease. Chemical name: Blood-coagulation factor V (12 Dec 1998) |
| acetate replacement factor | <biochemistry> 1,2 dithiolane 3 valeric acid. Regarded as a coenzyme in the oxoglutarate dehydrogenase complex of the citric acid cycle. Involved generally in oxidative decarboxylations of _ keto acids. A growth factor for some organisms. (18 Nov 1997) |
| adrenal weight factor | A postulated substance of adenohypophysial origin responsible for maintenance of the weight of the adrenal cortex. (05 Mar 2000) |
| adrenocorticotropic releasing factor | Hormone produced by hypothalamus that causes pituitary to secrete adrenocorticotropic hormone. (05 Mar 2000) |
| a-factor | <molecular biology> A protein which is found in the bacterial genus Streptomyces that helps start the production of streptomycin and the process of morphological differentiation. It is used in biotechnology to induce these functions in mutant strains of Streptomyces that cannot produce it themselves. (09 Feb 1998) |
| angiogenesis factor | Substance causing proliferation of new blood vessels. It is found in tissues with high metabolic requirements, such as the retina, and in certain cancers. The factor is also released by hypoxic macrophages at the edges or outer surfaces of wounds and initiates revascularization in wound healing. (12 Dec 1998) |
| animal protein factor | <biochemistry> Member of the water soluble B vitamin group, important in the proper function of the nervous system and important in proper carbohydrate, protein and fat metabolism. (27 Sep 1997) |
| antialopecia factor | A member of the vitamin B complex necessary for growth of yeast and of mice, absence from the diet causes hair loss and dermatitis in mice. (27 Sep 1997) |
| antianaemic factor | <biochemistry> Member of the water soluble B vitamin group, important in the proper function of the nervous system and important in proper carbohydrate, protein and fat metabolism. (27 Sep 1997) |
| antiberiberi factor | Synonym: thiamin. (05 Mar 2000) |