| Von Willebrand disease | <disease, haematology> A hereditary platelet disorder caused by defective or deficient Von Willebrand factor, a protein involved in normal blood clotting, that reduces adhesion to collagen but not aggregation. Both bleeding time and coagulation are increased. Factor VIII levels are secondarily reduced. Symptoms include nosebleeds, bleeding gums, heavy menstrual bleeding, bruising and skin rashes. Inheritance: autosomal dominant. (30 Sep 1997) |
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| von Willebrand, E | <person> Finnish physician, 1870-1949. See: von Willebrand's disease. (05 Mar 2000) |
| Von Willebrand factor | Plasma factor involved in platelet adhesion through an interaction with Factor VIII. See: Von Willebrand disease. (18 Nov 1997) |
| von Willebrand factor-degrading protease | <enzyme> A large protease from normal human plasma that degrades vwf at the 842tyr-843met peptide bond Registry number: EC 3.4.24.- Synonym: vwf-cleaving protease (26 Jun 1999) |
| Von Willebrand's disease | <disease> This congenital disease, which is caused a deficiency of a blood factor that promotes platelet adhesion, is characterised by prolonged bleeding and poor blood coagulation. (09 Oct 1997) |