| radiation inactivation | The technique of inactivating proteins in freeze dried (lyophilised) preparations using high energy particles (e.g. Electrons). One high energy particle can apparently inactivate all of the components of a multisubunit polypeptide, the method is therefore used to determine the molecular weight of functional oligomers. (18 Nov 1997) |
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| X inactivation | <cell biology> The inactivation of one or other of each pair of X chromosomes to form the Barr body in female mammalian somatic cells. Thus tissues whose original zygote carried heterozygous X borne genes should have individual cells expressing one or other but not both of the X borne gene products. The inactivation is thought to occur early in development and leads to mosaicism of expression of such genes in the body. See: Lyon hypothesis. (18 Nov 1997) |
| inactivation | <neurology, physiology> For example of voltage gated sodium channels: process by which sodium channels that have been activated or opened by depolarisation subsequently close during the depolarisation. Distinguished from activation by its slower kinetics. (18 Nov 1997) |
| insertional inactivation | The inactivation of a gene due to the insertion of exogenous genetic material into that gene. (14 Nov 1997) |
| enzyme inactivation | The disappearance of an enzyme's activity during in vitro conditions, such as during a lab preparation of the enzyme, where the enzyme is exposed to conditions not normally found within its environment inside a living cell (like different pH, excess or too little salt, temperature changes, etc.) (09 Oct 1997) |
| bovine virus diarrhoea virus | A virus of the genus Pestivirus, in the family Togaviridae, causing bovine virus diarrhoea; New York, Oregon, and Indiana strains of the virus are recognised. Synonym: mucosal disease virus. (05 Mar 2000) |
| abelson leukaemia virus | A defective murine leukaemia virus capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukaemia after superinfection with friend, moloney, or rauscher virus. (12 Dec 1998) |
| Abelson murine leukaemia virus | A retrovirus belonging to the Type C retrovirus group subfamily (family Oncovirinae) which is associated with leukaemia and produces in vitro transformation of mouse cells. (05 Mar 2000) |
| adeno-associated virus | <virology> A genus of viruses in the family Parvoviridae which are all defective viruses (unable to replicate by themselves) and depend on the co-infection of their host cell by other, nondefective viruses to help them replicate. (09 Oct 1997) |
| adenoidal-pharyngeal-conjunctival virus | <virology> An icosahedral (20-sided) virus that contains DNA, there are over 40 different adenovirus varieties, some of which cause the common cold. (10 May 1997) |
| adenosatellite virus | <virology> A genus of viruses in the family Parvoviridae which are all defective viruses (unable to replicate by themselves) and depend on the co-infection of their host cell by other, nondefective viruses to help them replicate. (09 Oct 1997) |
| african horse sickness virus | A species of orbivirus that causes disease in horses, mules, and donkeys. (12 Dec 1998) |
| african swine fever virus | The lone species of the genus african swine fever-like viruses. The virus causes a fatal disease among domestic pigs in africa and a less virulent infection in europe. The virus is present in soft ticks (ornithodoros moubata), warthogs, or domestic pigs. Originally listed as a species of iridoviridae, the virus exhibits some similarities to poxviridae but its differences warranted placement in a separate genus of an, as yet unknown, family. (12 Dec 1998) |
| AIDS-related virus | An obsolete term for human immunodeficiency virus. (05 Mar 2000) |
| Akabane virus | A virus of the genus Bunyavirus, family Bunyaviridae, causing abortion in cattle and congenital arthrogryposis and hydranencephaly in bovine foetuses in Israel, Japan, and Australia; it is transmitted by mosquitoes. (05 Mar 2000) |