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anaplastic large cell lymphoma <tumour> A form of lymphoma characterised by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2).
Synonym: Ki-1+ lymphoma.
(05 Mar 2000)
bilateral large kidneys <radiology> Autosomal dominant (adult) polycystic disease, lymphoma Cf: other urographic patterns
(12 Dec 1998)
carcinoma, large cell A tumour of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic.
(12 Dec 1998)
papillary adenoma of large intestine <tumour> Appears as a solitary sessile, often large, tumour of colonic mucosa composed of mucinous epithelium covering delicate vascular projections; malignant change occurs frequently; hypersecretion occurs rarely. Also known as adenoma.
Synonym: papillary adenoma of large intestine.
(05 Mar 2000)
ribulose-1,5-bisphosphate carboxylase-oxygenase large subunit epsilonN-methyltransferase <enzyme> An aspect of EC 2.1.1.43; trimethylates lys-14 of rubisco
Registry number: EC 2.1.1.-
Synonym: rubisco lsmt, rubisco large subunit lysine n-methyltransferase
(26 Jun 1999)
the large mass of the telencephalon On either side of the midline, consisting of the cerebral cortex and its associated fibre systems, together with the deeper-lying subcortical telencephalic nuclei (i.e., basal ganglia [nuclei]).
(05 Mar 2000)
unilateral large kidney <radiology> Multifocal: xanthogranulomatous pyelonephritis (XGP), malakoplakia, multicystic dysplastic kidney Cf: other urographic patterns
smooth kidney: renal vein thrombosis, acute arterial infarction, obstructive uropathy, acute bacterial nephritis, compensatory hypertrophy, duplicated pelvocalyceal system Cf: other urographic patterns
multifocal: solid neoplastic mass, malignant, adenocarcinoma, adult nephroblastoma, invasive transitional cell carcinoma, sarcoma, metastasis, benign, hamartoma, adenoma, mesenchymal tumour cystic mass, simple cyst, focal hydronephrosis, multilocular cystic nephroma, arteriovenous malformation Cf: other urographic patterns
(12 Dec 1998)
follicular predominantly large cell lymphoma <tumour> A B-cell lymphoma of intermediate malignancy.
(05 Mar 2000)
large 1. Exceeding most other things of like in bulk, capacity, quantity, superficial dimensions, or number of constituent units; big; great; capacious; extensive; opposed to small; as, a nlarge horse; a large house or room; a large lake or pool; a large jug or spoon; a large vineyard; a large army; a large city.
For linear dimensions, and mere extent, great, and not large, is used as a qualifying word; as, great length, breadth, depth; a great distance; a great height.
2. Abundant; ample; as, a large supply of provisions. "We hare yet large day." (Milton)
3. Full in statement; diffuse; full; profuse. "I might be very large upon the importance and advantages of education." (Felton)
4. Having more than usual power or capacity; having broad sympathies and generous impulses; comprehensive; said of the mind and heart.
5. Free; unembarrassed. "Of burdens all he set the Paynims large." (Fairfax)
6. Unrestrained by decorum; said of language. "Some large jests he will make."
7. Prodigal in expending; lavish.
8. Crossing the line of a ship's course in a favorable direction; said of the wind when it is abeam, or between the beam and the quarter. at large. Without restraint or confinement; as, to go at large; to be left at large. Diffusely; fully; in the full extent; as, to discourse on a subject at large. Common at large. See Common, Electors at large, Representative at large, electors, or a representative, as in Congress, chosen to represent the whole of a State, in distinction from those chosen to represent particular districts in a State. To give, go, run, or sail large, to have the wind crossing the direction of a vessel's course in such a way that the sails feel its full force, and the vessel gains its highest speed. See Large.
Synonym: Big, bulky, huge, capacious, comprehensive, ample, abundant, plentiful, populous, copious, diffusive, liberal.
Origin: F, fr. L. Largus. Cf. Largo.
Source: Websters Dictionary
(01 Mar 1998)
large breast lesions <radiology> Breast masses greater than 5 cm, lucent: lipoma, mixed lucent/opaque: fibro-adeno-lipoma, low-density opaque: giant fibroadenoma, cyst, cystosarcoma phylloides, mucinous carcinoma, high-density opaque (large and dense)
(12 Dec 1998)
large calorie The quantity of energy required to raise the temperature of 1 kg of water 1°C, more precisely from 14.5
large cell carcinoma A group of lung cancers in which the cells are large and look abnormal.
(12 Dec 1998)
large cell lymphoma <oncology, tumour> Highly malignant group of tumours arising from transformed lymphocytes or myeloid precursors. Cell of origin often obscure.
(18 Nov 1997)
large, dense breast lesions <radiology> Carcinoma, sarcoma, cystosarcoma phylloides, cyst, abscess, lymph nodes (lymphoma, leukaemia, metastasis)
(12 Dec 1998)
large gallbladder <radiology> Courvoisier phenomenon, neoplasm of pancreatic head, distal common bile duct, papilla, hydrops, empyema, vagotomy, diabetes (20% of DM patients) Cf: small gall bladder
(12 Dec 1998)
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